{"id":"W4412790822","doi":"10.1101/2025.07.26.666954","title":"Rewiring DNA repair with PARP-based chemical inducers of proximity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Donald E. and Delia B. Baxter Foundation","keywords":"Poly ADP ribose polymerase; DNA; Inducer; Computational biology; DNA repair; Genetics; Chemistry; Biology; Gene; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320899,0.0002437285,0.000218947,0.0001836031,0.0001259566,0.0004142731,0.0002705142,0.0002542839,0.001968813],"category_scores_gemma":[0.000214856,0.0001516042,0.0001502767,0.000140789,0.0003347927,0.000238772,0.0003190737,0.0009437982,0.0004111167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003756213,"about_ca_system_score_gemma":0.0001863251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001233132,"about_ca_topic_score_gemma":0.0002328719,"domain_scores_codex":[0.9998487,0.00002070447,0.00001142917,0.0000445899,0.00004801166,0.00002648251],"domain_scores_gemma":[0.9998631,0.0000266585,0.00005224894,0.00002469994,0.00000852516,0.0000247078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001495228,0.00006899497,0.0001662297,0.0000871537,0.000008158006,0.00006462196,0.00001524641,0.0005436724,0.9932179,0.001324538,0.0002469101,0.004107059],"study_design_scores_gemma":[0.00002944477,0.0002437389,0.0004013417,0.000003640712,0.000004879581,0.0000934448,0.000006318942,0.0009691304,0.9943128,0.0001623594,0.003768622,0.000004334848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454573,0.004534204,0.03561255,0.0007776484,0.0002223369,0.0002855295,0.0009602695,0.0008592496,0.01129074],"genre_scores_gemma":[0.9883242,0.0009833659,0.006855577,0.0001488687,0.00003092916,0.00007443233,0.0002600554,0.00003705992,0.003285523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968813,"threshold_uncertainty_score":0.006586313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942103811854323,"score_gpt":0.2549202066578404,"score_spread":0.2354991685392971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}