{"id":"W4412791461","doi":"10.1016/j.clinbiochem.2025.110980","title":"The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective","year":2025,"lang":"en","type":"review","venue":"Clinical Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Disease; Alzheimer's disease; Prospective cohort study; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005619745,0.0005272174,0.001824911,0.0001263332,0.000238097,0.00003738862,0.0004139714,0.0006864467,0.0001052245],"category_scores_gemma":[0.003811068,0.0003092449,0.001907292,0.0005709695,0.00115953,0.00001558879,0.0001513016,0.0006423625,0.00002362839],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002253258,"about_ca_system_score_gemma":0.01406067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009842556,"about_ca_topic_score_gemma":0.00007083609,"domain_scores_codex":[0.9965298,0.0003066967,0.001217481,0.000923241,0.0003675727,0.0006551726],"domain_scores_gemma":[0.994054,0.002246234,0.0004140701,0.001159445,0.0002706105,0.001855702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009919724,0.005569009,0.169272,0.02953216,0.1216208,0.002602523,0.000002738568,1.314076e-7,0.000001497834,0.00003270053,0.004755141,0.6656193],"study_design_scores_gemma":[0.01224257,0.002168664,0.01077406,0.1992867,0.2762214,0.00009992241,0.00007674278,0.0000654133,0.00168389,0.0003551561,0.493691,0.003334505],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000937708,0.9950141,4.225304e-7,0.0001797081,0.0001205811,0.001883256,0.001374952,0.0000341,0.000455169],"genre_scores_gemma":[0.007127933,0.9910325,0.0001085989,0.00008985077,0.0002409658,0.0005529617,0.0007786743,0.00003693089,0.00003154954],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6622848,"threshold_uncertainty_score":0.999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539278390344256,"score_gpt":0.4575556478774117,"score_spread":0.303627808842986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}