{"id":"W4412792386","doi":"10.1016/j.bbi.2025.106065","title":"Crosstalk between DNA damage and cGAS-STING immune pathway drives neuroinflammation and dopaminergic neurodegeneration in Parkinson’s disease","year":2025,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institute of Neurological Disorders and Stroke; Health Science Center, University of Tennessee; National Institute on Aging; National Institutes of Health","keywords":"Neurodegeneration; Neuroinflammation; Parkinson's disease; Dopaminergic; Neuroscience; Crosstalk; Immune system; Sting; Medicine; Disease; Immunology; Biology; Dopamine; Physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002029154,0.0003321705,0.0003387299,0.0003812546,0.0002659122,0.0004594933,0.0001558545,0.0005171403,0.001210072],"category_scores_gemma":[0.0001267043,0.0002427787,0.0003657172,0.0001438826,0.0004871308,0.0003138515,0.0003594377,0.0006231447,0.0001727991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005484311,"about_ca_system_score_gemma":0.000304855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00079151,"about_ca_topic_score_gemma":0.001586428,"domain_scores_codex":[0.99979,0.00003342256,0.00002111497,0.00006141671,0.00003763103,0.00005639904],"domain_scores_gemma":[0.9999043,0.000005220743,0.00004301719,0.00000664923,0.00001046202,0.00003027252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001888208,0.0001258702,0.02351273,0.0001391587,0.00009102689,0.000981303,0.0001590981,0.0002619926,0.9660569,0.000385399,0.0001885452,0.006209803],"study_design_scores_gemma":[0.0001489428,0.00199523,0.508356,0.0001132228,0.0004594712,0.004665364,0.001279709,0.005088368,0.4705473,0.001901046,0.005400345,0.00004500959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972851,0.001444937,0.0004840638,0.00008390896,0.00001320055,0.000008669946,0.0001489713,0.00002503192,0.0005061342],"genre_scores_gemma":[0.9987841,0.0003145684,0.0002436699,0.00003114507,0.000005908077,0.000008365977,0.00008447227,0.000002124854,0.0005255422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210072,"threshold_uncertainty_score":0.004048049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250576716938845,"score_gpt":0.2563788611589634,"score_spread":0.2438730939895749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}