{"id":"W4412793596","doi":"10.1038/s41419-026-08686-1","title":"The RIPK3-IL-6 axis mediates kidney injury in cytokine storm syndrome","year":2025,"lang":"en","type":"preprint","venue":"Cell Death and Disease","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Instituto de Salud Carlos III","keywords":"Necroptosis; Inflammasome; Cytokine storm; Kidney; Acute kidney injury; Bone marrow; Cancer research; Biology; Medicine; Inflammation; Cytokine; Cell biology; Immunology; Pathology; Programmed cell death; Internal medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225814,0.0006382677,0.000497359,0.0003509223,0.0002292248,0.0002871,0.0001857245,0.0004454721,0.001591794],"category_scores_gemma":[0.0001575136,0.0001681737,0.0008597567,0.0002032288,0.0004091659,0.000337532,0.0004761973,0.001285855,0.0004053678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003273583,"about_ca_system_score_gemma":0.0002889539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002334862,"about_ca_topic_score_gemma":0.0002846267,"domain_scores_codex":[0.9998031,0.00003973555,0.00002966982,0.00003823212,0.00004240074,0.0000468394],"domain_scores_gemma":[0.9998332,0.00001134213,0.00006433896,0.00001192194,0.00001126078,0.00006787763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001072989,0.00005625021,0.002589402,0.0001921847,0.0000375381,0.001033524,0.0000459908,0.0002265673,0.9918897,0.0003644231,0.0001657238,0.002325783],"study_design_scores_gemma":[0.0003661526,0.001630868,0.09480835,0.00006472136,0.0002601144,0.01260477,0.0002354088,0.004955195,0.8768719,0.001569573,0.006587577,0.0000453473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881662,0.0041081,0.005181334,0.0003522255,0.00006375335,0.00005467105,0.0006221118,0.0002180008,0.001233633],"genre_scores_gemma":[0.9951311,0.001503661,0.001945755,0.0001598757,0.00002493147,0.00004721589,0.0005111993,0.00002267313,0.0006536845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591794,"threshold_uncertainty_score":0.005325079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641063826587547,"score_gpt":0.3002673540117949,"score_spread":0.2838567157459194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}