{"id":"W4412796269","doi":"10.1101/2025.07.27.667059","title":"Aging-enhanced accumulation of fibroblasts excludes oligodendrocytes in demyelinated lesions","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hotchkiss Brain Institute; University of Saskatchewan; University of Calgary","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Chemistry; Cell biology; Pathology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002481652,0.0003275269,0.0002621888,0.0005062917,0.0002033963,0.0003766257,0.0001168345,0.0003541537,0.001820932],"category_scores_gemma":[0.0001461102,0.0002391053,0.0001859101,0.0001859187,0.0002484074,0.0003270713,0.0002604167,0.0003943695,0.0005955413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322479,"about_ca_system_score_gemma":0.0001382339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005274772,"about_ca_topic_score_gemma":0.0007306168,"domain_scores_codex":[0.9998922,0.00001177053,0.00001020336,0.00003277599,0.00003071107,0.00002220212],"domain_scores_gemma":[0.9998914,0.0000184343,0.00002484221,0.00001770064,0.00001739301,0.0000302573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224721,0.000007704412,0.0005506515,0.00003257449,0.000006857205,0.0002377885,0.00005398092,0.00003741992,0.9965048,0.0003170432,0.00009365688,0.002035117],"study_design_scores_gemma":[0.00001212833,0.000100573,0.01922476,0.00001455619,0.00002295429,0.001745571,0.00007445889,0.0005481478,0.9710161,0.0005874753,0.006645202,0.00000811573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771376,0.005967009,0.01049303,0.0001451057,0.0001083705,0.00001988952,0.0009060179,0.000249624,0.004973378],"genre_scores_gemma":[0.9797188,0.001972205,0.006310452,0.00009478115,0.00005332198,0.00003167863,0.0008364428,0.000108116,0.01087417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001820932,"threshold_uncertainty_score":0.006091595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05637148226585658,"score_gpt":0.2936308358339842,"score_spread":0.2372593535681277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}