{"id":"W4412798329","doi":"10.1139/cjpp-2025-0064","title":"KCNQ3 activation by the naturally occurring phenol, eugenol","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Eugenol; Chemistry; Ion channel; TRPV1; Pharmacology; Activator (genetics); Analgesic; Sodium channel; Biophysics; Transient receptor potential channel; Biochemistry; Medicine; Biology; Sodium; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008589476,0.0002062372,0.0001296507,0.00007594762,0.000131319,0.0001873653,0.0001499695,0.0002509333,0.00159843],"category_scores_gemma":[0.0001301294,0.00006210461,0.0002392882,0.0001059061,0.0001722796,0.0002563767,0.0002248025,0.0003001152,0.0001906537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455456,"about_ca_system_score_gemma":0.0002170248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001295059,"about_ca_topic_score_gemma":0.001462784,"domain_scores_codex":[0.9999214,0.00001267853,0.000005140205,0.00001628843,0.00001769483,0.00002679129],"domain_scores_gemma":[0.9999461,0.000009881957,0.00002154698,0.000005494549,0.000008002912,0.000008899349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001686928,0.00001129137,0.000139552,0.00007024422,0.000003891165,0.00003342328,0.000009725254,0.00006260426,0.9981368,0.0001317854,0.00004457264,0.001187403],"study_design_scores_gemma":[0.00003384896,0.0002085425,0.003855907,0.00001133573,0.00001404551,0.0002146242,0.00003724568,0.0007952417,0.9917325,0.0001982085,0.002890427,0.00000806943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988714,0.004632913,0.004263444,0.0003380353,0.00006328939,0.00002873666,0.0003484178,0.00004184518,0.00156922],"genre_scores_gemma":[0.995814,0.001536985,0.001349167,0.0001210625,0.00000691063,0.000009832529,0.0001522855,0.000007452531,0.001002304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159843,"threshold_uncertainty_score":0.005347252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007344520479572281,"score_gpt":0.2556180701399192,"score_spread":0.2482735496603469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}