{"id":"W4412804466","doi":"10.1101/2025.07.30.667769","title":"Modulation of the 14-3-3σ/C-RAF “auto”inhibited complex by molecular glues","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institute of General Medical Sciences; Deutsches Elektronen-Synchrotron; European Synchrotron Radiation Facility; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Ono Pharma Foundation; Diamond Light Source","keywords":"Modulation (music); Chemistry; Nanotechnology; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002795049,0.0004993662,0.0004302774,0.0001430403,0.0001551408,0.00008603379,0.0008416606,0.0006979574,0.00003616466],"category_scores_gemma":[0.0004071546,0.0004850527,0.000335926,0.000385314,0.0001956389,0.000009866796,0.001037557,0.000548,0.000009440686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176351,"about_ca_system_score_gemma":0.0004506571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009372075,"about_ca_topic_score_gemma":0.000004902361,"domain_scores_codex":[0.9974648,0.0002488395,0.0006180345,0.000925666,0.000360843,0.0003818665],"domain_scores_gemma":[0.996572,0.00002540218,0.0005774752,0.001958346,0.0007559185,0.0001108877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000323739,0.0001230974,0.001249315,0.0001906698,0.0002374391,0.000001917996,0.000003229906,0.0004865861,0.9933645,0.0002012746,0.004107145,0.000002480219],"study_design_scores_gemma":[0.0003648894,0.00004294037,0.01635698,0.0002964334,0.0001017365,1.931006e-8,0.000001700037,0.0007077483,0.9628928,0.000006654619,0.01877604,0.0004521088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850515,0.001386798,0.009400877,0.0005340447,0.001044054,0.00119229,0.001201074,0.0001105488,0.00007877543],"genre_scores_gemma":[0.9963729,0.0001010654,0.0026283,0.0003519053,0.0001741755,0.0002048671,0.0000103554,0.00007657068,0.00007987404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047172,"threshold_uncertainty_score":0.9997601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009833791723517761,"score_gpt":0.2332252204189757,"score_spread":0.2233914286954579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}