{"id":"W4412806376","doi":"10.1101/2025.07.25.666793","title":"Meningeal macrophages mask incision pain sensitization in male rats","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Krembil Foundation; University of Toronto","keywords":"Sensitization; Anesthesia; Central sensitization; Medicine; Neuroscience; Psychology; Internal medicine; Nociception","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358065,0.001033365,0.000569404,0.0007668078,0.0002819365,0.0003219849,0.0003304005,0.0004602594,0.004472728],"category_scores_gemma":[0.0001961161,0.0003441042,0.0003693346,0.0001940469,0.000596035,0.0003909021,0.0003884881,0.001235738,0.0009944552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925586,"about_ca_system_score_gemma":0.0004062864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004892073,"about_ca_topic_score_gemma":0.00116246,"domain_scores_codex":[0.999696,0.00003016249,0.00001645348,0.00007341058,0.0000907349,0.00009327098],"domain_scores_gemma":[0.9996502,0.00001996373,0.0001342554,0.00004220901,0.0000351841,0.0001181007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001191526,0.000377179,0.0005453398,0.00005285473,0.000009789317,0.00008451761,0.00003723373,0.00002940207,0.9946803,0.00007807981,0.00006536411,0.002848339],"study_design_scores_gemma":[0.0001015119,0.00409472,0.01262643,0.0000221667,0.00004316143,0.00032738,0.0001238594,0.0003148969,0.9807925,0.00007907817,0.001461373,0.00001304115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948564,0.0009910734,0.001915097,0.0002437469,0.00009723926,0.00007527465,0.0005026264,0.0001295798,0.00118907],"genre_scores_gemma":[0.9857211,0.001324804,0.002897205,0.0002191774,0.00007640765,0.0002124506,0.0004548986,0.00005441898,0.009039434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004472728,"threshold_uncertainty_score":0.01496279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128860707768233,"score_gpt":0.2397765322828425,"score_spread":0.2284879252051601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}