{"id":"W4412809447","doi":"10.1242/jcs.263539","title":"Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages","year":2025,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; The Scarborough Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Phagosome; Phagocytosis; Biology; Cell biology; Endosome; Endomembrane system; Macrophage; Receptor; Exocytosis; Secretion; Intracellular; Golgi apparatus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010561,0.000151399,0.0004444389,0.0001542394,0.0001192824,0.0003274063,0.0001948024,0.0003225284,0.0009275033],"category_scores_gemma":[0.0001606953,0.0001655547,0.0002048162,0.0001063176,0.0002838181,0.0002225358,0.000352105,0.0005067931,0.0003376619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613328,"about_ca_system_score_gemma":0.0001421361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002082463,"about_ca_topic_score_gemma":0.000234373,"domain_scores_codex":[0.9997962,0.00003471151,0.0000253168,0.00003488272,0.00003630676,0.00007262809],"domain_scores_gemma":[0.9998104,0.00003741087,0.00004565989,0.00002857879,0.00002159799,0.00005644022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002498722,0.0000308237,0.0004860486,0.00002524106,0.000003006329,0.00007735957,0.00003273658,0.00002706876,0.9984177,0.00007907305,0.00002078874,0.0005503347],"study_design_scores_gemma":[0.00003651848,0.0006592891,0.02473113,0.00001586725,0.00001787146,0.0005492818,0.0002195342,0.001650448,0.9704533,0.0001997791,0.001455848,0.00001116833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998705,0.0004303351,0.000482479,0.00004133715,0.000007924971,0.000005436991,0.00006304774,0.00001362893,0.0002507257],"genre_scores_gemma":[0.9984807,0.0001822996,0.0004173089,0.00004155353,0.00000497072,0.00001619352,0.0001005305,0.000008456221,0.0007478434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009275033,"threshold_uncertainty_score":0.003102839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006748681100054483,"score_gpt":0.2555004542181644,"score_spread":0.2487517731181099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}