{"id":"W4412815671","doi":"10.1038/s41467-025-62453-y","title":"Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Office of Extramural Research, National Institutes of Health; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; School of Medicine, Shanghai Jiao Tong University; National Health and Medical Research Council; International Microbiome Centre, University of Calgary; National Center for Research Resources; Canterbury Medical Research Foundation; Weill Cornell Medical College; Alberta Innovates; National Science Foundation; Shanghai Jiao Tong University; U.S. Department of Agriculture; Westfälische Wilhelms-Universität Münster; National Institutes of Health; U.S. Department of Health and Human Services; Yale University","keywords":"Staphylococcus aureus; Citric acid cycle; Metabolic pathway; Biology; Microbiology; Dimethyl fumarate; Fumaric acid; Staphylococcal infections; Enzyme; Immunology; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463597,0.0003208842,0.00029914,0.0001373319,0.0001361777,0.0003339559,0.0001460308,0.0003850418,0.001004485],"category_scores_gemma":[0.0001528415,0.0001071888,0.0001989258,0.0000750875,0.0002441979,0.0001756409,0.0003693658,0.0003992043,0.0002201982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711104,"about_ca_system_score_gemma":0.0002704552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089858,"about_ca_topic_score_gemma":0.001397684,"domain_scores_codex":[0.9997154,0.00006101516,0.00002092537,0.00005477872,0.00006968907,0.00007807203],"domain_scores_gemma":[0.9998569,0.00001618227,0.00003964012,0.00001195305,0.00002490362,0.00005030991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619811,0.00002124661,0.000525725,0.00002452661,0.000002511682,0.00004209152,0.00001296863,0.00002997332,0.9984908,0.00004574921,0.00002905022,0.0006133378],"study_design_scores_gemma":[0.00002332064,0.0009651755,0.03705335,0.00001825302,0.00002293572,0.0003454371,0.0001544883,0.0017129,0.956463,0.0001530331,0.003073451,0.00001466555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935416,0.003045695,0.001532154,0.0002113693,0.0000392744,0.00002543673,0.0003091823,0.00009215417,0.001202938],"genre_scores_gemma":[0.9974598,0.0005858581,0.000759317,0.0000712081,0.000009105114,0.00001953254,0.0001511184,0.00001056279,0.0009333704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089858,"threshold_uncertainty_score":0.003360331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009928452115053731,"score_gpt":0.2922523003669692,"score_spread":0.2823238482519155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}