{"id":"W4412818268","doi":"10.21769/bioprotoc.5422","title":"Assembly and Mutagenesis of Human Coronavirus OC43 Genomes in Yeast via Transformation-Associated Recombination","year":2025,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Coronavirus; Recombination; Mutagenesis; Transformation (genetics); Genetics; Biology; Genome; Yeast; Virology; Mutation; Gene; Computational biology; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005181867,0.0005963297,0.0004104821,0.0004242712,0.0004021885,0.000446794,0.0005548167,0.0004042897,0.001322457],"category_scores_gemma":[0.0003625932,0.0003751107,0.0004608039,0.0005039604,0.0003259034,0.0001769412,0.0006498521,0.0008379008,0.001112933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004416171,"about_ca_system_score_gemma":0.0005450607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002669792,"about_ca_topic_score_gemma":0.004250058,"domain_scores_codex":[0.9995648,0.00007392755,0.0000575598,0.00009401815,0.0001475297,0.00006209646],"domain_scores_gemma":[0.9998226,0.0000306337,0.00003740912,0.00005040668,0.00003498305,0.00002392241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007574678,0.00003566968,0.000161807,0.00009468022,0.00001125468,0.00008603377,0.00007322826,0.0003352001,0.994588,0.0005835791,0.0003129041,0.00364191],"study_design_scores_gemma":[0.00004466336,0.0001471176,0.001864339,0.00002489891,0.00003250922,0.0003823899,0.00006728349,0.003388782,0.9691911,0.0001820192,0.02465398,0.00002094598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.713438,0.001905196,0.2578999,0.0003672754,0.0002854214,0.002298587,0.0102641,0.002778592,0.01076295],"genre_scores_gemma":[0.7578456,0.003095674,0.1996764,0.0001690296,0.00003058572,0.001551484,0.02108915,0.001228578,0.01531334],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002669792,"threshold_uncertainty_score":0.005308568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263673247965873,"score_gpt":0.3519078569624783,"score_spread":0.3392711244828195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}