{"id":"W4412819807","doi":"10.1016/j.intimp.2025.115312","title":"A curcumin derivative metalloprotease inhibitor (CMC2.24) mitigates Brachyspira spp.-induced swine dysentery","year":2025,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; International Microbiome Centre, University of Calgary; Ministry of Economic Development and Trade, Government of Alberta; Cumming School of Medicine, University of Calgary; Agriculture Funding Consortium; Canada Foundation for Innovation; Results Driven Agriculture Research","keywords":"Dysentery; Curcumin; Microbiology; Derivative (finance); Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031161,0.0004967506,0.0004068325,0.000297101,0.0001302366,0.0001848744,0.0002044829,0.0003920225,0.001139028],"category_scores_gemma":[0.00008326379,0.000123092,0.0003465954,0.00007734072,0.0001547604,0.0002067349,0.0001609623,0.0005580721,0.0001478599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001517762,"about_ca_system_score_gemma":0.0002402827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008711116,"about_ca_topic_score_gemma":0.002158934,"domain_scores_codex":[0.999938,0.00001099412,0.00000487588,0.00001060015,0.00001271286,0.00002275898],"domain_scores_gemma":[0.9999415,0.00000533721,0.00001668681,0.000003492478,0.000009592485,0.00002345794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001277499,0.0003574502,0.0001658102,0.0002799146,0.00002646005,0.00007525261,0.00001579247,0.0001288651,0.9923528,0.00002178866,0.000160123,0.005138168],"study_design_scores_gemma":[0.0003115262,0.01674594,0.01273751,0.00007483448,0.0001517951,0.0004091424,0.0001099355,0.00139298,0.959343,0.00005660365,0.008641845,0.00002501667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911159,0.005461221,0.001328934,0.0001957051,0.0001078014,0.0001050119,0.0003394567,0.0001353345,0.001210683],"genre_scores_gemma":[0.9931292,0.002711767,0.001215476,0.0001393443,0.00002471589,0.0000626533,0.000372225,0.00001218992,0.00233241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139028,"threshold_uncertainty_score":0.003810406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04896082804934731,"score_gpt":0.384816212254967,"score_spread":0.3358553842056197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}