{"id":"W4412819807","doi":"10.1016/j.intimp.2025.115312","title":"A curcumin derivative metalloprotease inhibitor (CMC2.24) mitigates Brachyspira spp.-induced swine dysentery","year":2025,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; International Microbiome Centre, University of Calgary; Ministry of Economic Development and Trade, Government of Alberta; Cumming School of Medicine, University of Calgary; Agriculture Funding Consortium; Canada Foundation for Innovation; Results Driven Agriculture Research","keywords":"Dysentery; Curcumin; Microbiology; Derivative (finance); Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002227696,0.0003836815,0.0004367463,0.0005354704,0.0001842488,0.00006724881,0.0005805144,0.0001486964,0.006236346],"category_scores_gemma":[0.0003094607,0.0003755836,0.0002474661,0.0003360815,0.0001947041,0.0004910693,0.0004313143,0.000447809,0.0005987306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002741554,"about_ca_system_score_gemma":0.0001972182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002795556,"about_ca_topic_score_gemma":0.000004088203,"domain_scores_codex":[0.997763,0.0002640468,0.0006825748,0.0005638958,0.0002933146,0.0004331204],"domain_scores_gemma":[0.9987342,0.000267795,0.0002287552,0.000297635,0.0003429351,0.0001286157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002017966,0.0009047451,0.002582187,0.00006170596,0.001364691,0.001154555,0.0001664871,0.0000068697,0.9617324,0.0004875798,0.02711558,0.002405182],"study_design_scores_gemma":[0.0206073,0.007764454,0.06414692,0.0007603567,0.001113086,0.002430318,0.001177658,0.002705752,0.4624585,0.003607283,0.4312503,0.001978053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696785,0.0007193115,0.0002522439,0.003715661,0.00745774,0.0006137372,0.0000764504,0.000249065,0.01723725],"genre_scores_gemma":[0.9888872,0.00005835481,0.0001351412,0.005729335,0.0007230138,0.0004103069,0.0001428054,0.00003926333,0.003874582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.499274,"threshold_uncertainty_score":0.9998696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04896082804934731,"score_gpt":0.384816212254967,"score_spread":0.3358553842056197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}