{"id":"W4412825620","doi":"10.1093/hmg/ddaf126","title":"Huntingtin reduction results in altered nuclear structure and heterochromatic instability","year":2025,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Huntingtin; Biology; Hippocampal formation; Huntingtin Protein; Gene knockdown; Cell biology; Heterochromatin; Neuroscience; Organelle; Trinucleotide repeat expansion; Genetics; Mutant; Gene; Allele; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064396,0.0001759582,0.0002237613,0.0001617764,0.0001166818,0.0002920851,0.0001702054,0.0002604818,0.0008711461],"category_scores_gemma":[0.0001144217,0.0001383701,0.0001397032,0.0001046771,0.0002682242,0.0001673718,0.0002153996,0.0003988091,0.0002461977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002652621,"about_ca_system_score_gemma":0.0001589609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393356,"about_ca_topic_score_gemma":0.003434549,"domain_scores_codex":[0.9998782,0.00001011913,0.00001180994,0.00004142086,0.0000428798,0.0000155752],"domain_scores_gemma":[0.9999018,0.00001633299,0.00004096561,0.00001240085,0.00001024781,0.00001824241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002053547,0.000005753367,0.000147355,0.00001388864,0.000004241927,0.00006510066,0.00001658471,0.00001522001,0.9991783,0.00005285811,0.00001549048,0.0004646707],"study_design_scores_gemma":[0.000006060502,0.0001411994,0.0243229,0.00001060743,0.00001830921,0.0007694204,0.00007035257,0.0005131927,0.9724476,0.0001075264,0.001587593,0.000005276504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923009,0.001316226,0.004132225,0.00006410332,0.00002568093,0.0000183567,0.0003469286,0.0001002102,0.001695437],"genre_scores_gemma":[0.993117,0.0008880072,0.002664061,0.00005840226,0.000003627612,0.00002310796,0.0003925803,0.00002873556,0.002824391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393356,"threshold_uncertainty_score":0.00291431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828298710755913,"score_gpt":0.276437402220039,"score_spread":0.2581544151124799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}