{"id":"W4412846782","doi":"10.1101/2025.07.31.667977","title":"RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Courtois Foundation; Université du Québec à Montréal","keywords":"GTPase; Small GTPase; Cell biology; Chemistry; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001966428,0.0003690562,0.0002409645,0.0002033451,0.0003188754,0.0004300792,0.000289983,0.0003692554,0.001155625],"category_scores_gemma":[0.000182648,0.0001527297,0.0003202024,0.0001064582,0.0002566174,0.0001863439,0.0003991075,0.0003487863,0.0008043392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009043787,"about_ca_system_score_gemma":0.0002640107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001631944,"about_ca_topic_score_gemma":0.002200153,"domain_scores_codex":[0.9997904,0.00004102825,0.00001501309,0.00004776248,0.00005355831,0.00005228312],"domain_scores_gemma":[0.9998783,0.00001285287,0.00004474726,0.000009812248,0.00001805017,0.00003632691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002492172,0.00002894023,0.001511754,0.0000459341,0.00001237191,0.0001295764,0.00001964973,0.0003639061,0.9945555,0.0002798222,0.000161263,0.002642099],"study_design_scores_gemma":[0.00003852256,0.00009722855,0.0346687,0.00003048696,0.00002005786,0.0003574084,0.00007829121,0.01368656,0.945645,0.0001739679,0.005188694,0.00001499767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925661,0.001454762,0.003658232,0.0001352534,0.00001833849,0.00001340341,0.0002471282,0.000233278,0.00167342],"genre_scores_gemma":[0.9961255,0.0003428551,0.00137129,0.00004205152,0.000002877048,0.00002138039,0.0002203678,0.00003176423,0.001841845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631944,"threshold_uncertainty_score":0.006561756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101511870927545,"score_gpt":0.200819740967049,"score_spread":0.1898046222577736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}