{"id":"W4412850511","doi":"10.1016/j.ajt.2025.07.023","title":"Changes in the Duration and Severity of BK Viral Load May as a Surrogate Outcome in Trials to Advance New Therapeutics for BK Virus","year":2025,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Providence Health Care Research Institute; Providence Health Care; University of British Columbia","funders":"","keywords":"Medicine; BK virus; Viral load; Duration (music); Surrogate endpoint; Outcome (game theory); Virology; Internal medicine; Virus; Kidney transplantation; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03115001,0.001083919,0.002564789,0.000845144,0.0007700231,0.002838307,0.0006864848,0.001485369,0.005640504],"category_scores_gemma":[0.0280288,0.0003240887,0.00175729,0.001234902,0.001036477,0.003068247,0.0009097825,0.002393261,0.00118731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001065369,"about_ca_system_score_gemma":0.00158617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004715158,"about_ca_topic_score_gemma":0.001452917,"domain_scores_codex":[0.9811279,0.01456601,0.001859345,0.0006376355,0.001254293,0.0005548605],"domain_scores_gemma":[0.9777361,0.0106439,0.007334373,0.001251328,0.001643141,0.00139109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2871026,0.008277642,0.2320306,0.00749624,0.006324127,0.0004806939,0.000574814,0.007232457,0.02392029,0.008861685,0.01247322,0.4052256],"study_design_scores_gemma":[0.05097986,0.2852184,0.4797589,0.003929431,0.006875447,0.001461234,0.001062002,0.01558988,0.03085974,0.02950042,0.09433384,0.0004308907],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8138922,0.0689166,0.03779853,0.01445836,0.006069709,0.007720174,0.007035254,0.0004338297,0.0436753],"genre_scores_gemma":[0.9630889,0.006209075,0.01483884,0.003720776,0.001337976,0.004099989,0.002583069,0.00005912512,0.004062252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03115001,"threshold_uncertainty_score":0.164739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03460361854861502,"score_gpt":0.3787300290869086,"score_spread":0.3441264105382936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}