{"id":"W4412851612","doi":"10.1016/j.ajt.2025.07.1641","title":"Trial Design of the Phase 2 Study SHAMROCK Evaluating the Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Adult Kidney Transplant Recipients with Antibody-Mediated Rejection","year":2025,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Argenx; CSL Behring","keywords":"Medicine; Tolerability; Kidney transplant; Clinical trial; Kidney transplantation; Intensive care medicine; Kidney; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003300353,0.001645534,0.002219741,0.000485397,0.0005673295,0.000874159,0.0008403963,0.001645685,0.01081543],"category_scores_gemma":[0.003156594,0.0006228737,0.001383084,0.0003192067,0.001376671,0.001336267,0.000463966,0.002169121,0.001262026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007379983,"about_ca_system_score_gemma":0.002108777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006683819,"about_ca_topic_score_gemma":0.001262434,"domain_scores_codex":[0.9986947,0.0008404195,0.00006056349,0.0001612379,0.00007101634,0.0001719344],"domain_scores_gemma":[0.9987854,0.0004043432,0.0002237357,0.000138739,0.0001007018,0.0003470079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9791604,0.006288548,0.0007611939,0.0002738606,0.0004194031,0.00004278075,0.00004425256,0.0004392223,0.002305065,0.0004080821,0.000713915,0.009143277],"study_design_scores_gemma":[0.9145243,0.08208717,0.001033732,0.00002129111,0.0002669049,0.00002973581,0.00001871007,0.0004885615,0.0003373561,0.0003455004,0.000830753,0.00001609117],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9588483,0.001681658,0.002790317,0.001521608,0.0007518323,0.02630915,0.001937584,0.0002177134,0.005941743],"genre_scores_gemma":[0.945533,0.0009495073,0.005358704,0.002063065,0.0007883766,0.03852172,0.001516674,0.00004979691,0.005219167],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01081543,"threshold_uncertainty_score":0.03618127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02601705946205232,"score_gpt":0.3692944075806809,"score_spread":0.3432773481186286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}