{"id":"W4412852276","doi":"10.1016/j.ajt.2025.07.629","title":"An Immortalized Renal Proximal Tubule Epithelial Cellular Model Overexpressing Organic Anion Transporters 1 &amp; 3 for Characterizing the Cellular Uptake and Intrinsic Clearance Interactions Involving Mycophenolic Acid","year":2025,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Proximal tubule; Transporter; Mycophenolic acid; Organic anion transporter 1; Cell biology; Organic cation transport proteins; Medicine; Kidney; Biophysics; Biochemistry; Endocrinology; Chemistry; Internal medicine; Biology; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000431507,0.0003460195,0.0004596861,0.0004216424,0.0005206944,0.000630646,0.0004783782,0.0005795067,0.00135403],"category_scores_gemma":[0.0001864985,0.0002446376,0.0005194083,0.0004699167,0.0003262814,0.0005185622,0.0002783606,0.001382045,0.0007339665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083768,"about_ca_system_score_gemma":0.0004835789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146808,"about_ca_topic_score_gemma":0.001589494,"domain_scores_codex":[0.9995779,0.00005781825,0.00005116496,0.00006969478,0.0001541095,0.00008940713],"domain_scores_gemma":[0.9996738,0.0000721988,0.00005517127,0.00008933609,0.00005189806,0.00005757826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467995,0.00006002592,0.0001550638,0.00002949898,0.000006468355,0.0001102104,0.0000396732,0.0001340697,0.9982445,0.0005295615,0.00006005936,0.0004840565],"study_design_scores_gemma":[0.0000184539,0.0002373655,0.001390992,0.00000390736,0.00003089498,0.000302498,0.00006448887,0.002677111,0.9906121,0.0001194455,0.00453376,0.000008953927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597294,0.001443045,0.03235859,0.0004584657,0.0002674912,0.00009190907,0.002693745,0.0003461197,0.002611258],"genre_scores_gemma":[0.9749488,0.00103647,0.01470546,0.0001284457,0.00003930888,0.0001051376,0.002199414,0.0000659653,0.006771016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135403,"threshold_uncertainty_score":0.004529715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008716431144617206,"score_gpt":0.2525998504149435,"score_spread":0.2438834192703263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}