{"id":"W4412855970","doi":"10.1021/jacsau.5c00584","title":"Programmable Single-Stranded Circular Antisense Oligonucleotides for Multitarget Gene Therapy","year":2025,"lang":"en","type":"article","venue":"JACS Au","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Advanced Education","funders":"Beijing Municipal Natural Science Foundation; National Key Research and Development Program of China; Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"Oligonucleotide; Gene silencing; Nucleic acid; Genetic enhancement; Gene; Computational biology; Chemistry; Biology; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184695,0.0001477755,0.0001483006,0.00004442368,0.000103389,0.00004330987,0.000161347,0.0001331978,0.000008448748],"category_scores_gemma":[0.00004094319,0.0001365107,0.0001516121,0.00007495401,0.00005454689,0.000004083427,0.00003630072,0.0000439513,0.000007114998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001721998,"about_ca_system_score_gemma":0.00009803421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004859811,"about_ca_topic_score_gemma":0.00003811179,"domain_scores_codex":[0.9991247,0.00002361292,0.0001741589,0.0003238184,0.00006085631,0.0002928584],"domain_scores_gemma":[0.9994777,0.00001071864,0.0000441019,0.0002999582,0.0001215824,0.00004591002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000189504,0.0001347331,0.001535614,0.00002595698,0.0001327425,0.000003013311,0.00003352741,0.00004777602,0.9777482,0.00003202822,0.002739615,0.01737729],"study_design_scores_gemma":[0.001048108,0.0003582086,0.001189361,0.00001657604,0.00001681409,0.000003547348,0.00003900484,0.000153189,0.8976561,0.0001826892,0.0991787,0.0001577463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901354,0.00125121,0.006741908,0.0001996274,0.0002871237,0.0004365953,0.00002957771,0.00002292622,0.0008955975],"genre_scores_gemma":[0.9945158,0.0003353768,0.002664948,0.0005080458,0.0001768,0.00006904134,0.0001602629,0.00001837065,0.001551351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09643909,"threshold_uncertainty_score":0.5566744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02155199345037679,"score_gpt":0.2734369205805321,"score_spread":0.2518849271301553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}