{"id":"W4412855970","doi":"10.1021/jacsau.5c00584","title":"Programmable Single-Stranded Circular Antisense Oligonucleotides for Multitarget Gene Therapy","year":2025,"lang":"en","type":"article","venue":"JACS Au","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Advanced Education","funders":"Beijing Municipal Natural Science Foundation; National Key Research and Development Program of China; Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"Oligonucleotide; Gene silencing; Nucleic acid; Genetic enhancement; Gene; Computational biology; Chemistry; Biology; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257097,0.0003097966,0.0001780601,0.00018249,0.0001101219,0.0002696992,0.000203046,0.0003993271,0.0006685816],"category_scores_gemma":[0.0001542516,0.0001320992,0.0001683952,0.0001035764,0.0002887336,0.0002494322,0.0001963131,0.0003351449,0.0002284444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002815709,"about_ca_system_score_gemma":0.0002488502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002501045,"about_ca_topic_score_gemma":0.0004868101,"domain_scores_codex":[0.9998662,0.00002237156,0.000009503987,0.00003859164,0.00004474258,0.00001849831],"domain_scores_gemma":[0.9999232,0.0000164982,0.00002851058,0.000006249525,0.00001340008,0.00001213811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002184767,0.000009767024,0.00004256328,0.00007335805,0.000004792321,0.00003438573,0.000015065,0.0002038505,0.9935336,0.001019618,0.00007723778,0.004963968],"study_design_scores_gemma":[0.00001127733,0.0002670364,0.0002012036,0.000009087152,0.00001301461,0.0001467309,0.0000108595,0.002048102,0.986793,0.0002462956,0.01024178,0.00001152045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7329514,0.02151993,0.2288636,0.0006999391,0.0005676719,0.0004177944,0.0003326509,0.001147371,0.01349974],"genre_scores_gemma":[0.9450035,0.005318542,0.04437285,0.0002778701,0.00005144062,0.0001363073,0.0001102684,0.00005053903,0.00467855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006685816,"threshold_uncertainty_score":0.002236664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02155199345037679,"score_gpt":0.2734369205805321,"score_spread":0.2518849271301553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}