{"id":"W4412866634","doi":"10.1101/2025.08.01.668251","title":"Early-Life Poultry-Derived Lactobacilli Drive Microbial Succession and Gut Immune Modulation in Broiler Chickens","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Animal Nutrition and Physiology","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of General Medical Sciences; Clemson University; National Institute of Food and Agriculture; National Institutes of Health; South Carolina Department of Agriculture; U.S. Department of Agriculture","keywords":"Broiler; Immune modulation; Gut microflora; Immune system; Ecological succession; Biology; Lactobacillus; Animal science; Food science; Ecology; Bacteria; Immunology; Genetics; Fermentation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427899,0.0002335935,0.0002413577,0.000131587,0.0000898939,0.0003022809,0.00009785098,0.0002275453,0.0006414482],"category_scores_gemma":[0.0001702999,0.0001465536,0.0001816424,0.00006131447,0.0001564444,0.0001281131,0.0001975401,0.0005101497,0.000187804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787361,"about_ca_system_score_gemma":0.0001766393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015763,"about_ca_topic_score_gemma":0.002322096,"domain_scores_codex":[0.9998964,0.00001749638,0.000007907518,0.00002818363,0.00002030111,0.00002978861],"domain_scores_gemma":[0.9998933,0.00001635244,0.00003025747,0.00000902829,0.00001293483,0.00003801541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003928649,0.00003931653,0.0008676057,0.00003202642,0.000004385789,0.00001973595,0.00002667998,0.00002781158,0.9970481,0.000009174462,0.00001599772,0.001516291],"study_design_scores_gemma":[0.00004178542,0.002242967,0.1120938,0.00004039467,0.00005347945,0.0001112591,0.0002256055,0.0007300929,0.8826829,0.00005652694,0.001709341,0.00001193374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983807,0.0004392501,0.0005588208,0.00004407916,0.00001207109,0.000009097776,0.0001703932,0.00001415894,0.0003715737],"genre_scores_gemma":[0.9956558,0.0004828332,0.001619623,0.0000884998,0.000006692038,0.00003191162,0.0002309031,0.00001944836,0.001864362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015763,"threshold_uncertainty_score":0.002145827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300041623480555,"score_gpt":0.2083949186212912,"score_spread":0.1953945023864856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}