{"id":"W4412866693","doi":"10.1016/j.canlet.2025.217961","title":"BCL-2/BCL-XL dual inhibition triggers Gasdermin D-mediated pyroptosis in mantle cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Studio; University of Texas MD Anderson Cancer Center; Eastern Virginia Medical School; AbbVie; AstraZeneca Canada; AstraZeneca","keywords":"Mantle cell lymphoma; Pyroptosis; Dual (grammatical number); Cancer research; Lymphoma; Mantle (geology); Programmed cell death; Biology; Apoptosis; Geology; Immunology; Geochemistry; Genetics; Art","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009480011,0.0001801801,0.000164792,0.0001393339,0.00006148883,0.00002348861,0.0001089403,0.0001445444,0.00004488373],"category_scores_gemma":[0.00002149721,0.0001915769,0.00009661052,0.0002533025,0.00008837535,0.000008737114,0.00006084873,0.00008133845,0.00002924454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008706123,"about_ca_system_score_gemma":0.0001308089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001317999,"about_ca_topic_score_gemma":0.00009717816,"domain_scores_codex":[0.99892,0.00005411658,0.0002499098,0.0003456431,0.00009329651,0.0003370143],"domain_scores_gemma":[0.9996128,0.00001149346,0.00006658926,0.0002423019,0.00003118131,0.0000356464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001252635,0.00006999432,0.002754811,0.0000482429,0.00003410649,0.00001365816,0.0001002314,0.0001088198,0.9527545,0.000006196984,0.03919486,0.004789306],"study_design_scores_gemma":[0.003680092,0.00004864654,0.005454065,0.00006909739,0.00002517592,0.00000152505,0.0002183693,0.0000444735,0.8659441,0.00001003881,0.1242005,0.0003038162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919024,0.002031983,0.0001275713,0.002939944,0.0003754155,0.0002073104,0.00002303651,0.00001724475,0.002375109],"genre_scores_gemma":[0.9895594,0.001038425,0.00003421587,0.007665949,0.00009422124,0.0001181924,0.0002532955,0.00002209953,0.001214275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08681036,"threshold_uncertainty_score":0.781228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003245336694206709,"score_gpt":0.2199026900259892,"score_spread":0.2166573533317825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}