{"id":"W4412867120","doi":"10.1101/2025.08.01.668025","title":"SUMO proteases SPF1/2 inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian AIDS Society","funders":"Arizona Biomedical Research Commission; Chinese Academy of Sciences; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Proteases; Biosynthesis; Biochemistry; Chemistry; Computational biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243978,0.0004061481,0.0002957388,0.0001720783,0.0001469476,0.0003002411,0.0002266588,0.0002595655,0.001820687],"category_scores_gemma":[0.0001552057,0.0001493044,0.0002928315,0.0001207492,0.0001609032,0.00016613,0.0002200874,0.0004622558,0.0005465124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024811,"about_ca_system_score_gemma":0.0002145305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734489,"about_ca_topic_score_gemma":0.0006330147,"domain_scores_codex":[0.9998925,0.00001764094,0.00001000413,0.00002076672,0.00002974673,0.00002932736],"domain_scores_gemma":[0.99993,0.00001195077,0.00001809592,0.00001167688,0.000009057046,0.00001916501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002841149,0.00003215512,0.000333992,0.0000340954,0.00001323331,0.00003977024,0.000006393567,0.0001341181,0.9969494,0.0001193736,0.0001633418,0.001890043],"study_design_scores_gemma":[0.00003454466,0.00009042165,0.001945022,0.00000203178,0.000008525692,0.00009712685,0.000007720043,0.00167827,0.993987,0.00006429391,0.002082312,0.000002683498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874681,0.00324135,0.006166089,0.0002778666,0.00008296034,0.0000344451,0.0006239329,0.0001903494,0.001914741],"genre_scores_gemma":[0.9887611,0.0009221651,0.004303865,0.00008859782,0.00002065312,0.00003408104,0.0008019614,0.00005805534,0.005009406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001820687,"threshold_uncertainty_score":0.00609082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008412449696128477,"score_gpt":0.2057935602334777,"score_spread":0.1973811105373492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}