{"id":"W4412871508","doi":"10.1101/2025.07.16.663652","title":"Age-dependent tumor-immune interactions underlie immunotherapy response in pediatric cancer","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Health and Medical Research Council; Stan Perron Charitable Foundation","keywords":"Immune system; Immunotherapy; Cancer immunotherapy; Cancer; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306553,0.0002435636,0.000223473,0.000234905,0.0001022797,0.0002674173,0.0001489793,0.0001967578,0.001342702],"category_scores_gemma":[0.0002075033,0.0001141714,0.000190521,0.0001147312,0.0001624744,0.0002452252,0.0002284084,0.0005189617,0.0002262128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002746738,"about_ca_system_score_gemma":0.0002330609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002695151,"about_ca_topic_score_gemma":0.0004427128,"domain_scores_codex":[0.9998603,0.00002790125,0.00001039648,0.00003619796,0.00002913718,0.00003613167],"domain_scores_gemma":[0.9997873,0.00002142351,0.000114377,0.00001466151,0.00001802464,0.00004421188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001428308,0.0001727099,0.09269245,0.000188987,0.00005293178,0.0005950756,0.0001339843,0.0005478832,0.882835,0.0005931808,0.0007501505,0.02000936],"study_design_scores_gemma":[0.0000508496,0.002779692,0.6610639,0.00006850174,0.0002180083,0.006809041,0.0003537338,0.002477863,0.3116945,0.0006024113,0.01385698,0.00002456486],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99367,0.003207127,0.001530461,0.00009119583,0.0000177546,0.0000220148,0.0005086735,0.0000350935,0.0009176632],"genre_scores_gemma":[0.9969632,0.001238743,0.0006393266,0.0000580681,0.000016481,0.00003436473,0.000449101,0.00001034964,0.0005902809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342702,"threshold_uncertainty_score":0.004491806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837602643065038,"score_gpt":0.2792116682294223,"score_spread":0.2608356417987719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}