{"id":"W4412885342","doi":"10.1093/brain/awaf286","title":"Haematopoietic stem cell transplant versus immune-reconstitution therapy in relapsing multiple sclerosis","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré de Santé et Services Sociaux de Chaudière-Appalache; St. Michael's Hospital; Ottawa Hospital; Cegep de Saint Jerome; University of Ottawa","funders":"Ms. Foundation for Women; National Health and Medical Research Council; Multiple Sclerosis Australia","keywords":"Alemtuzumab; Cladribine; Medicine; Expanded Disability Status Scale; Multiple sclerosis; Internal medicine; Hematopoietic stem cell transplantation; Stem cell; Transplantation; Oncology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005059365,0.0002052537,0.0006041296,0.0004220321,0.0001697477,0.0003518221,0.0002567973,0.0003706685,0.001101579],"category_scores_gemma":[0.004035982,0.0000890107,0.0007281712,0.0004532574,0.0005065121,0.0003125574,0.0003604201,0.0003436671,0.0001335262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307702,"about_ca_system_score_gemma":0.0004864116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003418672,"about_ca_topic_score_gemma":0.0005338157,"domain_scores_codex":[0.9947142,0.004654346,0.0002172632,0.0001728179,0.0001509063,0.00009039604],"domain_scores_gemma":[0.9984937,0.0007790385,0.0004022647,0.0001568572,0.00003834033,0.0001297436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6196408,0.005114546,0.1008424,0.001182326,0.00526932,0.0002949426,0.000400246,0.002730566,0.004004549,0.001920142,0.0007495848,0.2578507],"study_design_scores_gemma":[0.1298538,0.5787436,0.2582103,0.0003852306,0.006024855,0.001094028,0.0004357515,0.006877044,0.008400248,0.003973142,0.00594794,0.00005411007],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948226,0.004012141,0.0004138489,0.0001038538,0.00004507391,0.0001429734,0.00006263385,0.000005067721,0.0003918734],"genre_scores_gemma":[0.9983298,0.001014144,0.0002803176,0.0001067181,0.00004539699,0.00005955008,0.0000610952,0.000001021004,0.0001019699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005059365,"threshold_uncertainty_score":0.02675676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08276729039664442,"score_gpt":0.306380828420845,"score_spread":0.2236135380242006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}