{"id":"W4412890704","doi":"10.3389/fonc.2025.1537087","title":"Evolutionary dynamics of recurrent hepatocellular carcinoma under divergent immune selection pressures","year":2025,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute; Canadian Liver Foundation; Canadian Institutes of Health Research; Government of Ontario","keywords":"Hepatocellular carcinoma; Cohort; Immunosuppression; Immune system; Exome sequencing; Medicine; Malignancy; Oncology; Internal medicine; Biology; Immunology; Mutation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001229007,0.0001834878,0.0005675385,0.001026556,0.0006175654,0.001075074,0.0003592156,0.0004504218,0.001487185],"category_scores_gemma":[0.004688773,0.0001692951,0.0003359416,0.001081902,0.0005734247,0.0006861051,0.001035626,0.0006012769,0.0003406581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005335738,"about_ca_system_score_gemma":0.0003117997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471316,"about_ca_topic_score_gemma":0.002866675,"domain_scores_codex":[0.9991758,0.0002607417,0.00004670215,0.0002620369,0.0001189998,0.0001356938],"domain_scores_gemma":[0.9986255,0.0005353485,0.0003722035,0.00015141,0.0001600383,0.0001554617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000831043,0.000072131,0.8923622,0.0001663366,0.0006999592,0.001534221,0.002924589,0.006287077,0.04743927,0.00304794,0.00114057,0.04349467],"study_design_scores_gemma":[0.00001845189,0.0001465365,0.9749694,0.00005287502,0.0001329431,0.002171705,0.001497984,0.009569008,0.002643619,0.004623322,0.004113119,0.00006095083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974321,0.0004410464,0.001013363,0.0001663631,0.000004813604,0.000004178289,0.000325669,0.00001591048,0.0005966591],"genre_scores_gemma":[0.9980148,0.0002410666,0.0005449666,0.00009124837,0.000008603517,0.00001159799,0.0008407917,0.00002196943,0.0002249655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487185,"threshold_uncertainty_score":0.006499648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006047072740219758,"score_gpt":0.2452757809191822,"score_spread":0.2392287081789624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}