{"id":"W4412891107","doi":"10.3390/plants14152395","title":"HPLC-ESI-HRMS/MS-Based Metabolite Profiling and Bioactivity Assessment of Catharanthus roseus","year":2025,"lang":"en","type":"article","venue":"Plants","topic":"Phytochemistry and Biological Activities","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"Korea Environmental Industry and Technology Institute; University Grants Commission- Nepal; National Research Foundation of Korea","keywords":"Catharanthus roseus; Chemistry; Tandem mass spectrometry; Metabolite; Chromatography; Primary metabolite; Glucuronate; High-performance liquid chromatography; Electrospray ionization; Biochemistry; Mass spectrometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744535,0.0001175397,0.0002370511,0.000009139828,0.0001030304,0.00002246052,0.0001219002,0.00008644028,0.00004601658],"category_scores_gemma":[0.00003778393,0.00004217136,0.00005312993,0.0001262055,0.0001181043,0.00005991599,0.00005303718,0.000100666,6.147828e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001012417,"about_ca_system_score_gemma":0.00001601808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000855522,"about_ca_topic_score_gemma":0.00002104104,"domain_scores_codex":[0.9992721,0.00005555218,0.0001527706,0.0002344744,0.0001025201,0.000182552],"domain_scores_gemma":[0.9994923,0.0003183121,0.0000776545,0.00004296417,0.00002440777,0.00004437011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005059745,0.0001451308,0.05868135,0.00003115601,0.00001879167,0.000002061085,0.000004415247,0.000001286511,0.9163642,0.0001329348,0.00000962106,0.02455845],"study_design_scores_gemma":[0.0001097143,0.00005868672,0.3666184,0.00002545708,0.00001143347,0.000001171369,0.00004158484,0.0002217799,0.6317202,0.0002647027,0.0008427254,0.00008417631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949102,0.0002531347,0.00001546363,0.0002127071,0.00005416595,0.0001355469,0.0003880253,0.00003457232,0.003996162],"genre_scores_gemma":[0.999361,0.00005349755,0.0002037578,0.00009113701,0.00004310037,0.00001533855,0.0000808739,2.767959e-7,0.0001510361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3079371,"threshold_uncertainty_score":0.1719698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01980820028150298,"score_gpt":0.2637952315994246,"score_spread":0.2439870313179216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}