{"id":"W4412892773","doi":"10.1530/rep-24-0467","title":"Major depressive disorder and anti-depressant therapy markedly alters the human follicular niche DNA methylome","year":2025,"lang":"en","type":"article","venue":"Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto; CReATe Fertility Centre","funders":"","keywords":"DNA methylation; Epigenome; Epigenetics; Transcriptome; Methylation; Major depressive disorder; Biology; Follicular phase; CpG site; Internal medicine; Endocrinology; Bioinformatics; Medicine; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004767536,0.0001400051,0.0001234101,0.00004776528,0.0002913852,0.00004656058,0.00012155,0.0001063934,0.000007812688],"category_scores_gemma":[0.0001153149,0.0001025879,0.00006983658,0.0001280901,0.00009565674,0.000005953612,0.00008733819,0.00008971246,0.000001237756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008209208,"about_ca_system_score_gemma":0.00002173291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007072958,"about_ca_topic_score_gemma":0.00001382283,"domain_scores_codex":[0.9987969,0.0001592225,0.0001944953,0.0005859974,0.0001062483,0.0001570687],"domain_scores_gemma":[0.9990948,0.00001471292,0.00009217881,0.0006857936,0.00008487293,0.00002761125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002924736,0.00004070531,0.01868088,0.00001235162,0.0001088343,4.838577e-7,0.0000387279,0.000134082,0.9573443,0.0001208538,0.0002791529,0.0232104],"study_design_scores_gemma":[0.000560072,0.00005821833,0.09394304,0.00000885195,0.00004146117,0.000002553116,0.00005243382,0.00002552074,0.8422343,0.0008085016,0.06213254,0.0001325082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647546,0.03090484,0.002035996,0.001110516,0.0002593424,0.0003603197,0.000002952744,0.00001542936,0.0005560385],"genre_scores_gemma":[0.9937117,0.004518203,0.0001313696,0.0000856089,0.0002527918,0.00005007189,0.00004812295,0.0000168016,0.001185381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.11511,"threshold_uncertainty_score":0.4183412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013522881030788,"score_gpt":0.2764121767880663,"score_spread":0.2662769479777585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}