{"id":"W4412907488","doi":"10.3390/jpm15080338","title":"Effectiveness of Psychological Therapy for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-Analysis","year":2025,"lang":"en","type":"review","venue":"Journal of Personalized Medicine","topic":"Treatment of Major Depression","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut national de psychiatrie légale Philippe-Pinel; Université de Montréal","funders":"Canadian Institutes of Health Research; Eli Lilly Canada; Eli Lilly and Company","keywords":"Meta-analysis; Depression (economics); Medicine; Randomized controlled trial; Systematic review; Major depressive disorder; Cognitive behavioral therapy; Cognitive therapy; Clinical psychology; Population; Pharmacotherapy; Treatment-resistant depression; MEDLINE; Cognition; Psychotherapist; Psychiatry; Internal medicine; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.002808746,0.0006775699,0.02197252,0.001255575,0.00003199151,0.000005430787,0.0002126111,0.0003243426,0.0001770929],"category_scores_gemma":[0.001513427,0.0002786476,0.004476614,0.0010034,0.0001505307,0.00005230882,0.00002363986,0.0002543533,3.697513e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830604,"about_ca_system_score_gemma":0.0002143254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001768299,"about_ca_topic_score_gemma":0.000002224272,"domain_scores_codex":[0.9943665,0.001627014,0.002606759,0.000502568,0.0006674441,0.0002297366],"domain_scores_gemma":[0.9924089,0.003749146,0.002701264,0.0005429321,0.0003991784,0.0001986116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002383089,0.000782071,0.00002362479,0.8698465,0.1202753,0.0001349736,0.00006580698,8.027487e-8,0.000008297448,0.000007932639,0.00007750053,0.006394847],"study_design_scores_gemma":[0.007367451,0.002426659,0.00005306663,0.4360394,0.5516949,0.0001869764,0.00002086786,4.66429e-7,0.000002270026,0.000009740333,0.002097095,0.0001011511],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005494606,0.9919252,0.00008345815,0.000256876,0.00005528955,0.007491245,0.00007839694,0.000008379003,0.00004616949],"genre_scores_gemma":[0.0001633323,0.9978747,0.000474527,0.0001172912,0.00004510553,0.0008491692,0.00007832183,0.00003216331,0.000365361],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4338071,"threshold_uncertainty_score":0.9999666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1032235546999636,"score_gpt":0.4573151782408803,"score_spread":0.3540916235409167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}