{"id":"W4412907802","doi":"10.1016/j.bneo.2025.100148","title":"Targeting CDK9 inhibits the growth of KMT2A-rearranged infant leukemia and demonstrates synergy with menin inhibition","year":2025,"lang":"en","type":"article","venue":"Blood Neoplasia","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Alberta Children's Hospital Foundation","keywords":"Growth inhibition; Leukemia; Cancer research; Chemistry; Biology; Genetics; Cell growth","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001737214,0.000191603,0.0003268483,0.0001815588,0.0001304294,0.00002931486,0.00008227848,0.00001877249,0.00001465042],"category_scores_gemma":[0.0003929453,0.0001201871,0.00004143681,0.0005299357,0.0003021784,0.0001286508,0.00009140305,0.000330209,0.000002343846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002810783,"about_ca_system_score_gemma":0.0002877523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001922503,"about_ca_topic_score_gemma":0.0001377088,"domain_scores_codex":[0.9985865,0.0001009643,0.0003090905,0.0003108133,0.0003495428,0.0003431349],"domain_scores_gemma":[0.9991102,0.0002921254,0.0001121007,0.000213119,0.0001683258,0.0001040948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001151631,0.000243858,0.1232715,0.0008478429,0.0003231071,0.001315731,0.0002624843,0.00003580681,0.8661457,0.003725822,0.00148441,0.001192063],"study_design_scores_gemma":[0.00381742,0.0007736582,0.01244896,0.000803552,0.0002266716,0.0013221,0.0004916607,0.0001244445,0.9790407,0.0004495604,0.0003570877,0.0001441355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931418,0.001122877,0.00003115436,0.00168293,0.00002777861,0.0005324942,0.000008917796,0.0000615596,0.003390496],"genre_scores_gemma":[0.9983101,0.0002696205,0.0007656637,0.0001965507,0.00004091813,0.00005684828,0.00001528044,0.00002104989,0.0003239991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.112895,"threshold_uncertainty_score":0.4901086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005888901129144163,"score_gpt":0.2452559225787653,"score_spread":0.2393670214496212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}