{"id":"W4412920047","doi":"10.1021/acsomega.5c03645","title":"Synthesis and Biological Evaluation of Small Molecule Inhibitors of Immune Cytopenias","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; University Health Network","funders":"Canadian Blood Services","keywords":"Immune system; Chemistry; Pharmacology; Medicine; Computational biology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513272,0.0004407268,0.0002790034,0.0003707367,0.0001268978,0.0002512905,0.0002656327,0.0002551426,0.00300796],"category_scores_gemma":[0.0001483656,0.0001526971,0.000272125,0.0002703768,0.0001252708,0.0001901655,0.0001436683,0.0005461916,0.0005572779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290546,"about_ca_system_score_gemma":0.0002509756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005597451,"about_ca_topic_score_gemma":0.001329968,"domain_scores_codex":[0.9999347,0.000009705658,0.000006053996,0.00001257696,0.00002097968,0.00001595356],"domain_scores_gemma":[0.9999342,0.0000125018,0.00001230911,0.000007125283,0.00001620502,0.00001772694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000328804,0.0003650969,0.000156615,0.000290738,0.00003694592,0.0002962341,0.0000496523,0.001335889,0.9742212,0.0004203733,0.0005501381,0.02194833],"study_design_scores_gemma":[0.0006857144,0.01045256,0.003604184,0.00005431055,0.0001641968,0.0008103837,0.00006429173,0.001926261,0.9591509,0.0001640507,0.02288784,0.00003538125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498229,0.01753673,0.01211437,0.0003624695,0.0001623497,0.0009825247,0.002668366,0.0003899348,0.01596024],"genre_scores_gemma":[0.9634423,0.01254881,0.009311528,0.0002507687,0.00005208108,0.000302563,0.002848518,0.00004119257,0.01120236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00300796,"threshold_uncertainty_score":0.01006258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03399590636635005,"score_gpt":0.2953328886290456,"score_spread":0.2613369822626955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}