{"id":"W4412920047","doi":"10.1021/acsomega.5c03645","title":"Synthesis and Biological Evaluation of Small Molecule Inhibitors of Immune Cytopenias","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; University Health Network","funders":"Canadian Blood Services","keywords":"Immune system; Chemistry; Pharmacology; Medicine; Computational biology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002144631,0.0000579712,0.0002327,0.00007052243,0.00001424284,0.000001923537,0.00002862629,0.0000569371,0.00001145613],"category_scores_gemma":[0.0002135349,0.00004202365,0.00003688803,0.0001216508,0.00005099467,0.00001476975,0.000029855,0.0000310458,0.000001559941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001554724,"about_ca_system_score_gemma":0.00005058366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008442208,"about_ca_topic_score_gemma":0.000007276712,"domain_scores_codex":[0.9995242,0.00003562577,0.0001723182,0.0001005092,0.000101288,0.00006603786],"domain_scores_gemma":[0.9996585,0.0000670849,0.00005529682,0.0001141597,0.00008724201,0.00001766892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006201488,0.001419846,0.2788059,0.0002983464,0.001054039,0.00004770866,0.0004005859,0.00001016999,0.4662904,0.001172005,0.0003807869,0.2495],"study_design_scores_gemma":[0.002087646,0.0002190934,0.2822089,0.0001510098,0.000377817,0.000007411839,0.0001710756,0.00005590892,0.7140362,0.0005569069,0.00007493505,0.00005309304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943401,0.002039748,0.000004821612,0.0002506586,0.00002450252,0.0002340463,0.000004988588,0.000006154713,0.003094944],"genre_scores_gemma":[0.9996085,0.0001609938,0.0001023287,0.00002982923,0.000003398475,0.00001825416,0.000008878558,0.000002876955,0.00006497189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2494469,"threshold_uncertainty_score":0.1713675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03399590636635005,"score_gpt":0.2953328886290456,"score_spread":0.2613369822626955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}