{"id":"W4412928967","doi":"10.1016/j.immuni.2025.07.011","title":"From complexity to consensus: A roadmap for neutrophil classification","year":2025,"lang":"en","type":"review","venue":"Immunity","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Key Research and Development Program of China; National Medical Research Council; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; Natural Science Foundation of Beijing Municipality; Ministero della Salute; Ludwig Institute for Cancer Research; Israel Science Foundation; Else Kröner-Fresenius-Stiftung; European Research Council; Ministry of Health -Singapore; Fondazione Telethon; Fondation ISREC; Ministry of Science and Technology of the People's Republic of China; Deutsche Forschungsgemeinschaft; Rheumatology Research Foundation; Peabody Foundation; Cancer Research Society; Pfizer; National Natural Science Foundation of China; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Beijing Nova Program; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Computational biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003345105,0.001049736,0.002370434,0.003159447,0.0005466369,0.003513233,0.002131328,0.003067884,0.004939449],"category_scores_gemma":[0.004907948,0.0003281507,0.0006658092,0.002569967,0.002230597,0.005976895,0.002274658,0.005681857,0.00226992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002442769,"about_ca_system_score_gemma":0.004446975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001735743,"about_ca_topic_score_gemma":0.002801086,"domain_scores_codex":[0.9991577,0.0002252891,0.0001237493,0.0001343125,0.0002717852,0.00008722863],"domain_scores_gemma":[0.9973711,0.00134114,0.0001997419,0.0000891184,0.0007465715,0.0002523116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001302661,0.00005592116,0.0002646358,0.01093959,0.00007960181,0.0001375561,0.0001292437,0.000485333,0.0007652593,0.03587217,0.1258685,0.825272],"study_design_scores_gemma":[0.00002162904,0.00007279799,0.0003619193,0.005594747,0.00005474743,0.0003937269,0.0001674232,0.0001945568,0.0001282361,0.02411424,0.9688676,0.00002820953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005540535,0.9923849,0.0006453529,0.004538971,0.001617212,0.000005993396,0.00002441136,0.00001811631,0.000709607],"genre_scores_gemma":[0.001003308,0.9915685,0.001491766,0.002530497,0.002485665,0.00002032304,0.00007004166,0.000006528312,0.0008233245],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004939449,"threshold_uncertainty_score":0.01772356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1458226751724047,"score_gpt":0.3753592397622,"score_spread":0.2295365645897954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}