{"id":"W4412928969","doi":"10.1016/j.crmeth.2025.101120","title":"MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens","year":2025,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Bundesministerium für Bildung und Forschung; Cardiff University","keywords":"Chemistry; Ligand (biochemistry); Antigen; T-cell receptor; Vitamin b6; Reactive oxygen species; Biochemistry; Immunology; Medicine; Vitamin; Receptor; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001708437,0.0003057316,0.0005105715,0.0004482642,0.0004994699,0.0001450539,0.0001607908,0.0003995799,0.000847541],"category_scores_gemma":[0.0008286065,0.0002828864,0.0003002444,0.0004247802,0.0002518991,0.0003308414,0.0001561577,0.0005766932,0.0002630019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007344597,"about_ca_system_score_gemma":0.0001516011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000174054,"about_ca_topic_score_gemma":0.000004066726,"domain_scores_codex":[0.9973829,0.0006436962,0.0008314386,0.0006507742,0.0000595344,0.0004316948],"domain_scores_gemma":[0.9979299,0.0005689326,0.0005039405,0.0006506892,0.0003176648,0.00002889083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003718,0.0001261252,0.005352873,0.00005377713,0.0002628459,0.00005162604,0.0004213252,0.000005484579,0.9804661,0.000552739,0.002959812,0.009646908],"study_design_scores_gemma":[0.0002404359,0.00002818813,0.005499287,0.00004383764,0.0001030193,0.0001768001,0.0003605711,0.000002789031,0.6367105,0.0007785054,0.3558915,0.0001645207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7962632,0.01301053,0.02038034,0.0001008182,0.02997639,0.0004170987,0.000001980809,0.0002641227,0.1395855],"genre_scores_gemma":[0.6404803,0.0002831706,0.002895667,0.0003738414,0.00006214935,0.00003623957,0.0001317314,0.00002861745,0.3557083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3529317,"threshold_uncertainty_score":0.9999623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571213661863408,"score_gpt":0.3515902372148069,"score_spread":0.3358781005961728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}