{"id":"W4412930339","doi":"10.1016/j.maturitas.2025.108292","title":"Estetrol (E4) provides complete relief from vasomotor symptoms in one-third of participants in the E4COMFORT I phase 3 clinical trial","year":2025,"lang":"en","type":"article","venue":"Maturitas","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Women's Health Network","funders":"","keywords":"Medicine; Vasomotor; Clinical trial; Phase (matter); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007879714,0.000153088,0.000970675,0.0001307686,0.00004343644,0.00001747549,0.0001920145,0.0001532116,0.0000309489],"category_scores_gemma":[0.0005290837,0.0001010923,0.0001577895,0.0002512575,0.0001465842,0.00004781716,0.00009933765,0.0004661285,0.00001354165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001006712,"about_ca_system_score_gemma":0.00009596709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003882016,"about_ca_topic_score_gemma":0.000259505,"domain_scores_codex":[0.9979156,0.0002592795,0.0009302613,0.0003041771,0.0003034424,0.0002872183],"domain_scores_gemma":[0.9980984,0.001159561,0.0001241321,0.0005047019,0.00005882957,0.00005442609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.206543,0.04240238,0.4466063,0.001339114,0.006386456,0.001373312,0.01042631,0.000008659505,0.007757364,0.004702066,0.2295746,0.04288038],"study_design_scores_gemma":[0.3883922,0.006104832,0.389807,0.002994078,0.005504949,0.000009749577,0.002361489,0.001254881,0.001551806,0.003809857,0.1975977,0.0006114353],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881911,0.005003644,0.000004656539,0.003653637,0.0004570945,0.001204342,0.0000506079,0.00002808474,0.001406779],"genre_scores_gemma":[0.9950193,0.0001180297,0.0003072727,0.004048406,0.0002174088,0.0001064214,0.00002434892,0.00001004233,0.0001488203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818492,"threshold_uncertainty_score":0.4122424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1493939839602628,"score_gpt":0.40073596573999,"score_spread":0.2513419817797271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}