{"id":"W4412939282","doi":"10.1038/s42003-025-08561-3","title":"Network spreading and local biological vulnerability in amyotrophic lateral sclerosis","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"Amyotrophic lateral sclerosis; Atrophy; Neuroscience; Biology; Vulnerability (computing); Amygdala; Neuroimaging; Disease; Pathology; Medicine; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003117117,0.000223702,0.0002167558,0.001296997,0.0003101433,0.0005103112,0.0001892596,0.0002237888,0.000573522],"category_scores_gemma":[0.001424189,0.0001133725,0.0002517366,0.000847468,0.0005366947,0.0005144775,0.0005389774,0.0002178126,0.0000972661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004577117,"about_ca_system_score_gemma":0.0002776421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0213351,"about_ca_topic_score_gemma":0.03434434,"domain_scores_codex":[0.9998627,0.00002697718,0.000006397481,0.0000495099,0.00003326567,0.00002114787],"domain_scores_gemma":[0.9994343,0.0001962226,0.0001856151,0.00006452474,0.00006645106,0.00005289106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009271217,0.0001088224,0.6601007,0.0003727539,0.0008253417,0.001226131,0.002119485,0.1512837,0.08997358,0.006902298,0.004073399,0.08208667],"study_design_scores_gemma":[0.00001653735,0.00005300533,0.873123,0.00004464326,0.00009915154,0.0004362875,0.000478758,0.1121432,0.003506094,0.008521572,0.001545989,0.00003168931],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948034,0.0004146377,0.003625579,0.0000950924,0.000002421639,0.000005660171,0.0004926719,0.00005666629,0.0005039033],"genre_scores_gemma":[0.9973322,0.0001652576,0.001318133,0.00001262148,0.000005007318,0.000007761302,0.0008740488,0.00001265705,0.0002722588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0213351,"threshold_uncertainty_score":0.04242182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1154063202187573,"score_gpt":0.3740607918680282,"score_spread":0.258654471649271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}