{"id":"W4412943418","doi":"10.7150/thno.114534","title":"PTEN restoration and CXCR2 depletion synergistically enhance the effect of enzalutamide and inhibit bone metastatic CRPC","year":2025,"lang":"en","type":"article","venue":"Theranostics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Enzalutamide; PTEN; Cancer research; Chemistry; Androgen receptor; Prostate cancer; Medicine; Cancer; Internal medicine; Apoptosis; PI3K/AKT/mTOR pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264719,0.0005621684,0.000465871,0.0004148305,0.0001443622,0.0003150465,0.0003087234,0.0002866818,0.001692058],"category_scores_gemma":[0.00008310728,0.0001229636,0.00032848,0.0002347854,0.0003051182,0.0003034851,0.0002473611,0.0008830273,0.0003034515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004705021,"about_ca_system_score_gemma":0.0007080636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003350494,"about_ca_topic_score_gemma":0.008400023,"domain_scores_codex":[0.9998547,0.00001553165,0.000007647117,0.00001917878,0.00004483467,0.00005811601],"domain_scores_gemma":[0.9999676,0.000002786506,0.000005656342,0.000003413584,0.000004262425,0.00001636835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008919665,0.0007605464,0.0004148931,0.0002808555,0.00004978962,0.0001657957,0.00003384811,0.001113777,0.9707276,0.0006584768,0.00158692,0.02331561],"study_design_scores_gemma":[0.000334991,0.003899313,0.007225062,0.00002189519,0.000106594,0.0005699666,0.00006834268,0.003452222,0.9699071,0.00023377,0.0141527,0.00002809463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847318,0.004300058,0.002329294,0.0005017597,0.0001246977,0.0001445639,0.0008051242,0.0005532688,0.006509523],"genre_scores_gemma":[0.9923518,0.001432895,0.001528148,0.0001249751,0.00001337786,0.00008574093,0.0005431059,0.00002707536,0.003892845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003350494,"threshold_uncertainty_score":0.006662011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043598907467403,"score_gpt":0.3198032097475282,"score_spread":0.3093672206728542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}