{"id":"W4412951835","doi":"10.1002/1878-0261.70107","title":"Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer","year":2025,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Mary's Hospital Centre; Université Laval; McGill University; Queen's University; St. Mary's University; University of Toronto; McGill University Health Centre","funders":"Institute of Cancer Research; Fonds de Recherche du Québec - Santé; Cancer Research Society","keywords":"Merkel cell polyomavirus; Merkel cell carcinoma; Biology; Transcriptome; Merkel cell; Cell type; Cell; Downregulation and upregulation; Immune system; Cancer research; Gene; Immunology; Gene expression; Genetics; Carcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000167509,0.0001579433,0.000372442,0.0001999456,0.00004511047,0.000004109844,0.0001125233,0.0001943432,0.00001486202],"category_scores_gemma":[0.00009165105,0.0001192298,0.00009004899,0.000382996,0.0002225871,0.00001630949,0.00008740239,0.0002964767,0.000003340618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001768393,"about_ca_system_score_gemma":0.0005465248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005281148,"about_ca_topic_score_gemma":0.00001272432,"domain_scores_codex":[0.9989032,0.0001015167,0.000327775,0.000273962,0.0001323307,0.0002611904],"domain_scores_gemma":[0.9993626,0.00008398615,0.0001158409,0.0002676905,0.00005438118,0.0001154948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005675255,0.0005378941,0.01414467,0.0002468475,0.00004645262,0.0003980756,0.0003371592,0.0000815106,0.9812413,0.001456216,0.0007320395,0.0007210391],"study_design_scores_gemma":[0.01598083,0.001266892,0.05873154,0.0002641042,0.001480445,0.0001002635,0.0007246017,0.002955682,0.8406591,0.001644409,0.07559269,0.0005994171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532297,0.02477877,0.0007300639,0.001391953,0.0001555187,0.0003602967,0.000005511823,0.00001386056,0.01933438],"genre_scores_gemma":[0.9963879,0.00005311092,0.001096302,0.001758012,0.0000127411,0.00003068288,0.000008159058,0.00001717396,0.0006359392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1405822,"threshold_uncertainty_score":0.4862051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104659786816574,"score_gpt":0.2729750022720238,"score_spread":0.261928404403858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}