{"id":"W4412954308","doi":"10.1038/s41589-025-01982-5","title":"Intracrine FFA4 signaling controls lipolysis at lipid droplets","year":2025,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Wellcome; Directorate for Biological Sciences; Canadian Institutes of Health Research; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust","keywords":"Intracrine; G protein-coupled receptor; Perilipin; Cell biology; Intracellular; Lipolysis; Lipid droplet; Endoplasmic reticulum; Signal transduction; Biochemistry; Cell signaling; Lipid signaling; Chemistry; Biology; Receptor; Adipose tissue; Paracrine signalling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840159,0.0002641976,0.0003879054,0.00007565109,0.00009269483,0.00001537062,0.0003988444,0.001218989,0.000106837],"category_scores_gemma":[0.0006203686,0.0002097766,0.0002026754,0.0001809732,0.0001799786,0.000002636039,0.0003539111,0.0003948928,0.0000306927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002882559,"about_ca_system_score_gemma":0.00006487386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004065178,"about_ca_topic_score_gemma":0.000006489691,"domain_scores_codex":[0.9984536,0.00007885959,0.0003225246,0.0006289885,0.00008185898,0.0004342286],"domain_scores_gemma":[0.9991621,0.00009513419,0.00008882515,0.0004396217,0.0001070419,0.0001073031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002297131,0.00006871272,0.001251912,0.00002224409,0.0001570168,0.000001426272,0.000005610302,3.29636e-7,0.9853911,0.0004817374,0.003346615,0.009043614],"study_design_scores_gemma":[0.0004399136,0.00002473884,0.0001269449,0.000009957233,0.00004671226,0.000005016352,0.00000417387,0.000003606607,0.6590898,0.00007256382,0.3400229,0.0001536879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894324,0.006318656,0.0001589491,0.001110127,0.0006846327,0.0001584706,0.00004789166,0.00004201919,0.002046864],"genre_scores_gemma":[0.9928758,0.0002091908,0.000997085,0.003022617,0.001386649,0.00002870299,0.0004185188,0.0000170873,0.001044385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3366762,"threshold_uncertainty_score":0.9401958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003015398201029186,"score_gpt":0.2450995398652146,"score_spread":0.2420841416641854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}