{"id":"W4412957328","doi":"10.3389/fneur.2025.1630163","title":"Pharmacotherapy variability and precision medicine in neurocritical care","year":2025,"lang":"en","type":"review","venue":"Frontiers in Neurology","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Neurointensive care; Medicine; Intensive care medicine; Pharmacotherapy; Dosing; Neurology; Pharmacology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006414856,0.000699991,0.001503777,0.001753279,0.0005865694,0.004219315,0.001064779,0.00253619,0.003483736],"category_scores_gemma":[0.01599405,0.0002890255,0.001266542,0.001679563,0.002527621,0.003286952,0.001831581,0.003182024,0.0007210961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002462509,"about_ca_system_score_gemma":0.006065324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002853341,"about_ca_topic_score_gemma":0.003341266,"domain_scores_codex":[0.9944527,0.002460172,0.0007180881,0.0005820675,0.001532133,0.0002549365],"domain_scores_gemma":[0.979021,0.01617314,0.001917143,0.0004671451,0.002102765,0.0003188891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002436746,0.00008905876,0.004073097,0.02606406,0.000543533,0.0008774311,0.001359562,0.002123469,0.001372464,0.0808818,0.04779632,0.8345754],"study_design_scores_gemma":[0.00005020858,0.0002985192,0.005915025,0.02281085,0.0005585413,0.003090341,0.0008770566,0.001473834,0.001341551,0.06925394,0.8942033,0.0001268691],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001459557,0.968927,0.00513664,0.01775827,0.001307495,0.00003959681,0.0001436748,0.00006655115,0.005161153],"genre_scores_gemma":[0.04613834,0.9304867,0.00760484,0.009749765,0.004133881,0.0001299143,0.0001722992,0.00003654539,0.001547775],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006414856,"threshold_uncertainty_score":0.03392541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995174360081689,"score_gpt":0.3749377837324469,"score_spread":0.35498604013163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}