{"id":"W4412957356","doi":"10.3389/fped.2025.1559147","title":"Outpatient monthly plasmapheresis with post-PLEX evinacumab in pediatric homozygous familial hypercholesterolemia: a case report on port access and immunoglobulin preservation","year":2025,"lang":"en","type":"article","venue":"Frontiers in Pediatrics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Western Ontario; London Health Sciences Centre; Western University","funders":"Ultragenyx Pharmaceutical","keywords":"Plasmapheresis; Medicine; Familial hypercholesterolemia; Apheresis; Pediatrics; LDL apheresis; Polyclinic; Extracorporeal; Antibody; Intensive care medicine; Cholesterol; Internal medicine; Immunology; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003293809,0.001375347,0.001319857,0.001714866,0.001526725,0.00113346,0.0009161854,0.00292032,0.001021456],"category_scores_gemma":[0.00157629,0.0006200103,0.001060252,0.001035543,0.0010823,0.001399353,0.001069183,0.0033676,0.0003634378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001339854,"about_ca_system_score_gemma":0.001581864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002644573,"about_ca_topic_score_gemma":0.003682183,"domain_scores_codex":[0.9992946,0.00008308194,0.00009197331,0.0001968329,0.0001461604,0.0001873502],"domain_scores_gemma":[0.99913,0.0002324092,0.0001965253,0.00004821616,0.00004009592,0.000352742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00002176521,0.00005740072,0.00508406,0.00002067482,0.00000922014,0.991493,0.0001440565,0.0000619694,0.0005558587,0.0001889139,0.0002538645,0.002109159],"study_design_scores_gemma":[0.00000645245,0.00004067967,0.002401694,0.00001218011,0.00001159678,0.9963458,0.00005531375,0.0001444737,0.0003792012,0.00008234528,0.0005124189,0.000007789096],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643844,0.008904439,0.01055088,0.005504838,0.0005196842,0.0002213054,0.0003058091,0.0003863286,0.009222421],"genre_scores_gemma":[0.9887956,0.003587579,0.003812032,0.001394602,0.0007261302,0.00003979261,0.0001365989,0.00008043973,0.001427179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292032,"threshold_uncertainty_score":0.009721339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009629227216827482,"score_gpt":0.257298052882894,"score_spread":0.2476688256660665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}