{"id":"W4412957766","doi":"10.1136/bmjopen-2024-097134","title":"Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings","year":2025,"lang":"en","type":"article","venue":"BMJ Open","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Health and Long Term Care; Thunder Bay Regional Research Institute; NOSM University; Thunder Bay Regional Health Sciences Centre; Sunnybrook Health Science Centre; East Wellington Family Health Team; Manitoba Health; Research Manitoba; University of Saskatchewan; University of Alberta; University Health Network; McMaster University; Access Alliance Multicultural Health and Community Services; Université Laval; Providence Health Care; Humber River Regional Hospital; Université de Montréal; Centre Hospitalier de l’Université de Montréal; Université de Sherbrooke; Impact; South Health Campus; Women's College Hospital; North York General Hospital; St. Michael's Hospital; Queen's University; University of Ottawa; Dalhousie University; University of Manitoba; Jewish General Hospital; Simon Fraser University; Montreal General Hospital; University of Calgary; Institute for Clinical Evaluative Sciences; McGill University; Centre for Addiction and Mental Health; Élisabeth Bruyère Hospital; University of Toronto; Memorial University of Newfoundland; University of British Columbia; Toronto General Hospital; Public Health Ontario","funders":"Canadian Institutes of Health Research; Health Canada; University of Toronto; Public Health Agency; Public Health Agency of Canada","keywords":"Medicine; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Randomized controlled trial; 2019-20 coronavirus outbreak; Protocol (science); Pandemic; Trial registration; Sars virus; Alternative medicine; Virology; Outbreak; Infectious disease (medical specialty); Surgery; Internal medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02907761,0.005322285,0.005685069,0.001641135,0.00365319,0.004326456,0.003364764,0.006493085,0.05857776],"category_scores_gemma":[0.02768624,0.002259102,0.004344512,0.00276984,0.004027243,0.002543722,0.001769376,0.006636274,0.007895349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01377316,"about_ca_system_score_gemma":0.03420473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02885041,"about_ca_topic_score_gemma":0.06475652,"domain_scores_codex":[0.9795116,0.01261078,0.001828858,0.00216346,0.001802146,0.002083113],"domain_scores_gemma":[0.9887799,0.002797602,0.002424824,0.001529498,0.002318442,0.002149763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8747733,0.005873118,0.001213037,0.01361675,0.002322011,0.0003288187,0.000624213,0.003715126,0.001873592,0.01005344,0.05128343,0.03432308],"study_design_scores_gemma":[0.9127357,0.01393862,0.00280278,0.002311337,0.0009957614,0.00008004841,0.0001195663,0.002436545,0.0007185872,0.006115452,0.05760254,0.0001430765],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.00237239,0.0003641518,0.001300814,0.0004874681,0.0003424026,0.9893064,0.003151417,0.00008576866,0.002589144],"genre_scores_gemma":[0.005087296,0.0001803483,0.002649943,0.0003643302,0.00006651361,0.9902933,0.0005087242,0.000009167255,0.0008403659],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05857776,"threshold_uncertainty_score":0.1959621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5394323444180716,"score_gpt":0.6056711986177342,"score_spread":0.06623885419966258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}