{"id":"W4412973065","doi":"10.1097/ypg.0000000000000398","title":"Effects of DNA methylation and polygenic scores on self-reported suicidal ideation in psychoses: no evidence of epigenetic basis of polygenic risk","year":2025,"lang":"en","type":"article","venue":"Psychiatric Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Suicidal ideation; Polygenic risk score; DNA methylation; Schizophrenia (object-oriented programming); Epigenetics; Clinical psychology; Psychiatry; Genome-wide association study; Psychology; Medicine; Poison control; Genetics; Injury prevention; Biology; Gene; Genotype; Single-nucleotide polymorphism; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214189,0.0003873136,0.0002922381,0.0005385017,0.00027514,0.0003673618,0.0002427741,0.0003961677,0.003092778],"category_scores_gemma":[0.003023524,0.0002206676,0.0005240491,0.0004402421,0.0003944325,0.0002036434,0.0003817613,0.0003496204,0.0001678605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508975,"about_ca_system_score_gemma":0.0002738373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0021416,"about_ca_topic_score_gemma":0.00303948,"domain_scores_codex":[0.9993892,0.0002826057,0.00004255021,0.0001590716,0.00007516179,0.00005142476],"domain_scores_gemma":[0.9977865,0.0008693262,0.0006168298,0.0002985125,0.0001110716,0.0003176158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009132234,0.00005164687,0.9879986,0.0000206307,0.0006584624,0.0001054304,0.0001009625,0.00007290457,0.006409005,0.00008373598,0.0000363834,0.003549001],"study_design_scores_gemma":[0.000006146829,0.0001451666,0.9989406,0.000003882062,0.0001118972,0.0001262288,0.00002314737,0.0002216293,0.0002769254,0.00009781675,0.00004415561,0.000002383481],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987896,0.0002578341,0.0004088422,0.00005894932,0.000004354306,0.000005185435,0.0001856164,0.00000618641,0.0002833391],"genre_scores_gemma":[0.9995956,0.00004686292,0.0001661169,0.00001193607,0.00000285313,0.000002728662,0.00008796582,0.000001839679,0.00008408267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003092778,"threshold_uncertainty_score":0.01034635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007448886752762266,"score_gpt":0.2802332711139186,"score_spread":0.2727843843611563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}