{"id":"W4412975036","doi":"10.3390/ph18081161","title":"Design, Synthesis, and Bioactivity Assessment of Modified Vemurafenib Analog","year":2025,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Vemurafenib; Medicine; Melanoma; Cancer research; Metastasis; Matrix metalloproteinase; Drug resistance; Malignancy; V600E; Pharmacology; Oncology; Internal medicine; Metastatic melanoma; Cancer; Mutation; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126913,0.0002683631,0.0001535885,0.0001461636,0.0000860827,0.0001316986,0.00020544,0.0001730565,0.001115603],"category_scores_gemma":[0.0001214332,0.00006885828,0.0002040358,0.0001245126,0.00007983181,0.000142899,0.0001163571,0.0002191128,0.0002754222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711085,"about_ca_system_score_gemma":0.0001658012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002569043,"about_ca_topic_score_gemma":0.000375553,"domain_scores_codex":[0.99994,0.00001074765,0.000005491362,0.00001249761,0.000017052,0.00001416127],"domain_scores_gemma":[0.9999588,0.000004267891,0.00001354693,0.000003879931,0.00001027477,0.000009253393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002245884,0.0001579852,0.0001586164,0.000231489,0.00001801847,0.0001822761,0.00003465548,0.001931414,0.9859918,0.0003012657,0.0001192754,0.0106487],"study_design_scores_gemma":[0.0001215873,0.003632371,0.001319192,0.00001882653,0.00003614061,0.0005187443,0.00002395323,0.00241118,0.9811211,0.0001027364,0.01067327,0.00002077747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731798,0.003700543,0.01741518,0.0001048826,0.00004714749,0.0002897414,0.0005815062,0.00005738393,0.004623873],"genre_scores_gemma":[0.9892626,0.001372123,0.006868218,0.00003694947,0.000008159314,0.00007216274,0.0004185355,0.000009269516,0.001951934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115603,"threshold_uncertainty_score":0.003732026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04929140372200529,"score_gpt":0.373308055114508,"score_spread":0.3240166513925027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}