{"id":"W4412988177","doi":"10.1016/j.talanta.2025.128680","title":"A rapid and highly sensitive CRISPR assay utilizing Cas12a orthologs for the detection of Novel Duck Reovirus","year":2025,"lang":"en","type":"article","venue":"Talanta","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China; Innovative Research Group Project of the National Natural Science Foundation of China","keywords":"Chemistry; CRISPR; Computational biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677419,0.0000796173,0.0000901112,0.00002856885,0.0000617154,0.000007898295,0.00004922859,0.00007299786,5.662371e-7],"category_scores_gemma":[0.00008830226,0.00006314877,0.00004527165,0.00005281951,0.00004591671,0.000001284742,0.00005515764,0.00004599709,2.03697e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004254755,"about_ca_system_score_gemma":0.00001714382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004516001,"about_ca_topic_score_gemma":0.00009796843,"domain_scores_codex":[0.999567,0.00001324077,0.000109417,0.0001637368,0.00003523317,0.0001114179],"domain_scores_gemma":[0.9996854,0.00005884548,0.00003126692,0.0001613489,0.00004655216,0.00001659042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006869656,0.00001220689,0.0001508413,0.000032494,0.00005159639,6.082909e-7,0.00006553171,0.00004312276,0.9883552,0.00006632317,0.0001247767,0.01102867],"study_design_scores_gemma":[0.0004653804,0.00009148127,0.004932782,0.00001523059,0.00005011501,0.00002557908,0.0002912061,0.001165305,0.9824917,0.000008159153,0.01038828,0.00007480855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8772919,0.002351234,0.1191941,0.0001384736,0.0002107992,0.0002415266,0.00003776078,0.00001012299,0.0005240559],"genre_scores_gemma":[0.9989281,0.0003623119,0.0002398064,0.00008561205,0.00005730728,0.00001465753,0.00001212167,0.000007848043,0.000292292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1216362,"threshold_uncertainty_score":0.2575132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262316779763291,"score_gpt":0.292339052055619,"score_spread":0.2797158842579861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}