{"id":"W4412992962","doi":"10.1016/j.cmet.2025.07.006","title":"Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control","year":2025,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Van Andel Research Institute","keywords":"Glycosphingolipid; Function (biology); Biosynthesis; CD8; Cytotoxic T cell; Cell biology; Biochemistry; Chemistry; Biology; Immunology; Antigen; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003464174,0.0002211275,0.000247434,0.0001416471,0.0001714255,0.00009492411,0.0002061808,0.0001603098,0.0001341829],"category_scores_gemma":[0.00009473403,0.0002053796,0.0001076546,0.0001720978,0.00008102381,0.000009905191,0.0001342058,0.0001809235,0.00008538391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001283035,"about_ca_system_score_gemma":0.0001067954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005161454,"about_ca_topic_score_gemma":0.00001572865,"domain_scores_codex":[0.9985194,0.0001379929,0.0002603378,0.0005071018,0.0002165908,0.0003585794],"domain_scores_gemma":[0.9991735,0.00003208573,0.00008432073,0.0004336892,0.0001332835,0.0001431779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000254928,0.0001028696,0.0006803771,0.00006998309,0.00004045719,0.000002771727,0.00001149802,0.0000151901,0.9918064,0.0003193918,0.001242286,0.005453873],"study_design_scores_gemma":[0.001818645,0.00005652593,0.004579629,0.000007237111,0.00006466892,0.000002556946,0.00004679639,0.00009894449,0.7933763,0.0002381988,0.1995299,0.0001806409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660971,0.01477356,0.005834012,0.000389712,0.0005435883,0.0005648171,0.00003600599,0.000040441,0.01172079],"genre_scores_gemma":[0.9923317,0.0007847205,0.0002308823,0.0008118389,0.0002490595,0.00006678456,0.00002445564,0.00002615128,0.005474402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1984301,"threshold_uncertainty_score":0.8375136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004847076350918201,"score_gpt":0.2213106653973708,"score_spread":0.2164635890464526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}