{"id":"W4412995741","doi":"10.3390/metabo15080523","title":"Novel Lipid Biomarkers of Chronic Kidney Disease of Unknown Etiology Based on Urinary Small Extracellular Vesicles: A Pilot Study of Sugar Cane Workers","year":2025,"lang":"en","type":"article","venue":"Metabolites","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Occupational Safety and Health; National Institute of Environmental Health Sciences; Centers for Disease Control and Prevention; National Institutes of Health; Canadian Dairy Commission","keywords":"Urine; Kidney disease; Urinalysis; Urinary system; CD63; Lipidomics; Biomarker; Creatinine; Kidney; Tamm–Horsfall protein; Biology; Internal medicine; Physiology; Endocrinology; Medicine; Bioinformatics; Biochemistry; Microvesicles","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005665116,0.0009301198,0.0005711633,0.001109262,0.001803197,0.0007068531,0.0003226327,0.0007162958,0.001104355],"category_scores_gemma":[0.001001676,0.0002991317,0.0004765529,0.0005807907,0.0005369982,0.0003072154,0.0006138819,0.0004747117,0.0002292893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004547047,"about_ca_system_score_gemma":0.0006371141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01415503,"about_ca_topic_score_gemma":0.01191133,"domain_scores_codex":[0.999681,0.0000562351,0.00001323386,0.00009698705,0.00006083805,0.00009172327],"domain_scores_gemma":[0.9994271,0.00009969138,0.00007305662,0.00004932352,0.0001592787,0.0001916296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001804695,0.001860133,0.9636337,0.00009815437,0.0001298917,0.001532408,0.003094611,0.00005915028,0.02165614,0.00004100456,0.0001575011,0.005932507],"study_design_scores_gemma":[0.0000479058,0.00333948,0.9910348,0.00001105422,0.0001020409,0.0006160678,0.00283234,0.0002487121,0.001205986,0.00004229737,0.0005007839,0.00001858467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996177,0.00005548084,0.0001058453,0.000009116749,0.000003780883,0.00003909037,0.00006264443,0.000001591474,0.0001047432],"genre_scores_gemma":[0.9992101,0.00006015376,0.000193491,0.00003708554,0.000009536423,0.00002934885,0.0001031583,0.000002773191,0.0003543815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01415503,"threshold_uncertainty_score":0.02814525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478428629313843,"score_gpt":0.253261662953596,"score_spread":0.2384773766604575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}