{"id":"W4413005401","doi":"10.1016/j.ecoenv.2025.118813","title":"Zearalenone at environmental levels promoted ER- positive breast cancer cell lines through the hedgehog pathway","year":2025,"lang":"en","type":"article","venue":"Ecotoxicology and Environmental Safety","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Yunnan Provincial Science and Technology Department; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Hedgehog; Breast cancer; Hedgehog signaling pathway; Zearalenone; Cancer research; Chemistry; Internal medicine; Gynecology; Cancer; Oncology; Physiology; Biology; Medicine; Signal transduction; Biochemistry; Food science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348555,0.0003059208,0.0002484039,0.00001504393,0.0006367236,0.00001088026,0.0001947115,0.0002768881,0.0004667045],"category_scores_gemma":[0.000006140536,0.0002408503,0.0001199831,0.00003891071,0.0007156112,0.00001123789,0.0006328904,0.0001688598,0.00003304925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937151,"about_ca_system_score_gemma":0.00003116025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003239309,"about_ca_topic_score_gemma":0.0001632259,"domain_scores_codex":[0.9984924,0.0001635383,0.0002784679,0.0005758101,0.0001013873,0.0003884116],"domain_scores_gemma":[0.9994869,0.00004598336,0.00009756178,0.0003022255,0.000003759681,0.00006359667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003481617,0.0002992442,0.01502811,0.00001725274,0.0002659608,0.000009160032,0.0004945986,0.00008838123,0.9797141,0.00002671021,0.0008333584,0.002874976],"study_design_scores_gemma":[0.001400736,0.0003047017,0.3641651,0.00002520408,0.00009669222,0.00006592844,0.0007593516,0.00003271903,0.5927403,0.00005727722,0.03995638,0.0003956505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864108,0.007906828,0.0001244588,0.001352056,0.0002348382,0.000544055,0.001620575,0.00001509161,0.001791315],"genre_scores_gemma":[0.988008,0.003567159,0.00007267545,0.001510483,0.0001492705,0.0001024732,0.0002556444,0.00002528285,0.006309021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3869738,"threshold_uncertainty_score":0.9821593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006811008042369092,"score_gpt":0.2208119761667119,"score_spread":0.2140009681243428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}