{"id":"W4413006439","doi":"10.1128/mmbr.00165-25","title":"Biological relevance of <i>in vitro</i> cellular models to study varicella-zoster virus—host cell interactome: current limitations and future perspectives","year":2025,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Interactome; Biology; Context (archaeology); Cell type; Immune system; Cell; Cell culture; Varicella zoster virus; Computational biology; Immunology; Virus; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006407454,0.0009922344,0.001788665,0.001021923,0.0004199108,0.004073848,0.001806505,0.001235452,0.002139993],"category_scores_gemma":[0.003214729,0.0003285066,0.001101229,0.0008280488,0.001499746,0.002767214,0.001490239,0.002291545,0.0009841941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001122953,"about_ca_system_score_gemma":0.001206865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009780639,"about_ca_topic_score_gemma":0.001571267,"domain_scores_codex":[0.9972791,0.001355353,0.0002944586,0.0004541398,0.0004338664,0.0001831913],"domain_scores_gemma":[0.9939427,0.00317535,0.0005936121,0.0008819294,0.001089041,0.0003173744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009852002,0.0007140712,0.01591917,0.02506291,0.0006382968,0.000772929,0.001066101,0.003210689,0.6593583,0.02787978,0.01777285,0.2466197],"study_design_scores_gemma":[0.00008689969,0.002796162,0.04075278,0.005069571,0.001605614,0.003942044,0.004582071,0.01172437,0.3419007,0.03788913,0.5493721,0.0002786277],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1100513,0.7529773,0.09615126,0.01811437,0.002535186,0.0003891879,0.003701544,0.0007412697,0.01533864],"genre_scores_gemma":[0.3380488,0.567775,0.06957097,0.00643323,0.002756151,0.00137887,0.007914743,0.000342056,0.005780161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006407454,"threshold_uncertainty_score":0.03388625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05404851578282722,"score_gpt":0.3575356234646987,"score_spread":0.3034871076818715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}