{"id":"W4413006439","doi":"10.1128/mmbr.00165-25","title":"Biological relevance of <i>in vitro</i> cellular models to study varicella-zoster virus—host cell interactome: current limitations and future perspectives","year":2025,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Interactome; Biology; Context (archaeology); Cell type; Immune system; Cell; Cell culture; Varicella zoster virus; Computational biology; Immunology; Virus; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004082519,0.00058618,0.002849858,0.0004393181,0.0000771272,0.000008383357,0.0001466676,0.0005748254,0.00001715462],"category_scores_gemma":[0.00008853864,0.0003877124,0.0003759188,0.0004612871,0.000212264,0.00002282334,0.0002450829,0.0006256939,0.00002078455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006670023,"about_ca_system_score_gemma":0.0001056284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001272796,"about_ca_topic_score_gemma":0.000009739507,"domain_scores_codex":[0.9964902,0.001198097,0.0009760259,0.0009778024,0.0000234042,0.0003344275],"domain_scores_gemma":[0.9987276,0.0002760135,0.0003273454,0.0004730304,0.00008621864,0.0001098133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000100304,0.001850882,0.00007611502,0.004488956,0.0004301088,0.00005195614,0.0006120473,7.337825e-8,0.02521347,0.0001627933,0.00005904214,0.9669542],"study_design_scores_gemma":[0.0007704099,0.0007234548,0.000009295743,0.002355206,0.001178752,0.00007820074,0.000114886,3.350915e-7,0.0006603096,0.00003349105,0.9937683,0.0003073872],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006518228,0.9885563,0.0004850301,0.00005790208,0.0002482381,0.003690128,0.0002085667,0.00001577899,0.0002197993],"genre_scores_gemma":[0.003267461,0.99447,0.001102981,0.0001996172,0.0000502773,0.0004775418,0.0003536046,0.00002225231,0.00005627749],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9937092,"threshold_uncertainty_score":0.9998575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05404851578282722,"score_gpt":0.3575356234646987,"score_spread":0.3034871076818715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}