{"id":"W4413008751","doi":"10.1016/j.neuropharm.2025.110627","title":"Perinatal and prenatal alcohol exposure impairs striatal cholinergic function and cognitive flexibility in adult offspring","year":2025,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Initiative for Nordic Studies; Division of Mathematical Sciences; National Institute on Alcohol Abuse and Alcoholism","keywords":"Offspring; Cholinergic; Cognitive flexibility; Prenatal exposure; Cognition; Prenatal alcohol exposure; Flexibility (engineering); Psychology; Medicine; Developmental psychology; Pregnancy; Neuroscience; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008986613,0.0003167324,0.0002422153,0.0004633823,0.0001356167,0.0002190969,0.0001746569,0.0002464567,0.001121323],"category_scores_gemma":[0.0001396918,0.0001905497,0.0001739278,0.0001110068,0.0003290432,0.0001479111,0.000301693,0.000601751,0.0001221512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174955,"about_ca_system_score_gemma":0.0002430629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00320588,"about_ca_topic_score_gemma":0.006926465,"domain_scores_codex":[0.9998628,0.00001363274,0.00001167338,0.00004599155,0.00003965445,0.0000262542],"domain_scores_gemma":[0.9998527,0.00001185369,0.00006253707,0.00001122733,0.00001448883,0.00004717126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005540586,0.0001545316,0.006246305,0.00006724421,0.00003120065,0.0004168921,0.0001549018,0.00008956506,0.9805722,0.000202315,0.00007094267,0.01143975],"study_design_scores_gemma":[0.00004836335,0.002829685,0.368249,0.00007579452,0.0001655752,0.001503777,0.0006621582,0.00113783,0.6220749,0.0004590699,0.002758952,0.0000348392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977244,0.0007149022,0.0007459899,0.00005766449,0.00000851548,0.000006380914,0.0002419816,0.00003488893,0.0004652203],"genre_scores_gemma":[0.9953042,0.001208801,0.001074244,0.00006132042,0.000003548069,0.00003068442,0.0002244908,0.00001296288,0.002079705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00320588,"threshold_uncertainty_score":0.006374419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122589810334649,"score_gpt":0.2982456047638231,"score_spread":0.2859866237303582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}