{"id":"W4413008765","doi":"10.3390/vaccines13080835","title":"The Immunoproteasome Is Expressed but Dispensable for a Leukemia Infected Cell Vaccine","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institut Du Cancer de Montréal; Université de Montréal","keywords":"Oncolytic virus; Vesicular stomatitis virus; Leukemia; Biology; Virology; Cancer research; Virus; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688673,0.00019285,0.0001659646,0.0000579,0.0003303696,0.00008143259,0.0004772852,0.0001319757,0.00004598188],"category_scores_gemma":[0.0001501823,0.000137463,0.0001311264,0.0002137716,0.00001949562,0.000004685378,0.0001761112,0.0001044303,0.0000193003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003523813,"about_ca_system_score_gemma":0.0002513591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005779582,"about_ca_topic_score_gemma":0.0001907393,"domain_scores_codex":[0.9988207,0.00006551679,0.0002295026,0.0003700415,0.0001039324,0.000410265],"domain_scores_gemma":[0.9988011,0.00008403355,0.00006447344,0.0007701966,0.0002287963,0.00005139919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003119405,0.00004054662,0.0006882304,0.00004375766,0.00009164494,4.443865e-7,0.00001266004,0.00002934728,0.9559994,0.00002683647,0.03709112,0.002856614],"study_design_scores_gemma":[0.001886512,0.0006411072,0.001011589,0.00001309357,0.00001667612,7.517392e-7,0.00003168002,0.0002092427,0.8733227,0.0003373825,0.1223856,0.0001436103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918691,0.004536342,0.0005007519,0.001282411,0.0001697267,0.0008630178,0.00004269823,0.00002922662,0.0007067064],"genre_scores_gemma":[0.9694715,0.001270211,0.0001448262,0.0006357915,0.0002425221,0.0004774035,0.00009312827,0.00004145032,0.0276232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08529449,"threshold_uncertainty_score":0.5605578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009277139524828787,"score_gpt":0.2787863391496148,"score_spread":0.269509199624786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}