{"id":"W4413008892","doi":"10.1038/s41467-025-62528-w","title":"Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Reprogramming; Glioblastoma; Cancer research; DNA methylation; Epigenetics; Wnt signaling pathway; Biology; Stem cell; Neural stem cell; Astrocyte; Bioinformatics; Neuroscience; Gene; Gene expression; Cell biology; Genetics; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676359,0.0001779624,0.000348174,0.0003073463,0.0001225175,0.0003319226,0.0001649199,0.0002216206,0.001745534],"category_scores_gemma":[0.0003521202,0.0000847918,0.0002198477,0.0001723017,0.0001360925,0.0002220123,0.0003025958,0.0003348623,0.0002263021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517536,"about_ca_system_score_gemma":0.0001860584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005424429,"about_ca_topic_score_gemma":0.001104874,"domain_scores_codex":[0.9998677,0.00001704966,0.00000993148,0.00003842889,0.0000380069,0.00002886998],"domain_scores_gemma":[0.9999163,0.00001251537,0.00002754024,0.00001168988,0.00001760831,0.00001431141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005862494,0.00005270041,0.002803875,0.0001026951,0.00005921408,0.00005818974,0.00004430048,0.0003936364,0.9764365,0.000264246,0.0002568267,0.01894166],"study_design_scores_gemma":[0.00004039835,0.003294977,0.03263045,0.00003207934,0.0003029766,0.0006759114,0.0001665975,0.002802374,0.9433934,0.0007136739,0.01592668,0.00002054045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906796,0.004114711,0.002225811,0.0001627734,0.00005757294,0.00003488996,0.0008459394,0.0001488564,0.001729727],"genre_scores_gemma":[0.9951434,0.001647953,0.001045672,0.0001466481,0.00001281641,0.000037902,0.0009242733,0.00003892706,0.001002479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001745534,"threshold_uncertainty_score":0.005839348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02511060957941922,"score_gpt":0.3864402976812223,"score_spread":0.361329688101803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}