{"id":"W4413009000","doi":"10.1097/ppo.0000000000000778","title":"Modulating Redox Biology to Improve Radiation Responses","year":2025,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Radioresistance; Reactive oxygen species; Redox; Radiation therapy; Cancer research; Programmed cell death; Antioxidant; Oxidative stress; Biology; Tumor progression; Tumor microenvironment; Cell biology; Cell growth; Cancer; Radiobiology; Cancer cell; Bioinformatics; Chemistry; Medicine; Tumor cells; Biochemistry; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006674621,0.0002881328,0.0006640322,0.0001353524,0.000236269,0.00006496155,0.0005629493,0.00029177,0.00003947824],"category_scores_gemma":[0.0003078298,0.0001897873,0.0004055373,0.0002070099,0.00005008066,0.000003063348,0.0001852482,0.0004343021,0.000006582338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048019,"about_ca_system_score_gemma":0.001374371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004082425,"about_ca_topic_score_gemma":0.00002444172,"domain_scores_codex":[0.9983085,0.0003955495,0.0004824344,0.0003736287,0.0001035467,0.0003363594],"domain_scores_gemma":[0.9988219,0.00006239751,0.0004031401,0.0004799469,0.0001160295,0.0001165831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004832488,0.000005433896,0.000001642932,0.0004103696,0.0001767951,4.559077e-7,0.0000282476,0.000019895,0.002318659,0.00002823226,0.01317661,0.9837853],"study_design_scores_gemma":[0.0001970798,0.00007173378,0.00000685292,0.001076541,0.0003766772,0.00005954123,0.00001077472,0.000001773635,0.0003145346,0.000097069,0.9975716,0.0002158562],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001218243,0.9928212,0.0006735672,0.0002129889,0.005301849,0.0004208128,0.0001750345,0.000007382768,0.0002653044],"genre_scores_gemma":[0.00003606406,0.9840472,0.0001441681,0.0004757616,0.01175928,0.0001384005,0.00005167683,0.00003411198,0.003313283],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.984395,"threshold_uncertainty_score":0.7739301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263204099523836,"score_gpt":0.3631089124495317,"score_spread":0.3404768714542933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}