{"id":"W4413009000","doi":"10.1097/ppo.0000000000000778","title":"Modulating Redox Biology to Improve Radiation Responses","year":2025,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Radioresistance; Reactive oxygen species; Redox; Radiation therapy; Cancer research; Programmed cell death; Antioxidant; Oxidative stress; Biology; Tumor progression; Tumor microenvironment; Cell biology; Cell growth; Cancer; Radiobiology; Cancer cell; Bioinformatics; Chemistry; Medicine; Tumor cells; Biochemistry; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003736025,0.0006596206,0.0009611932,0.001446917,0.0002294113,0.0008624578,0.0006699929,0.0010745,0.003984306],"category_scores_gemma":[0.0004586253,0.000227421,0.0004512332,0.00094067,0.0003049129,0.0009046014,0.0006043498,0.001936822,0.002411861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005553902,"about_ca_system_score_gemma":0.000570185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005512228,"about_ca_topic_score_gemma":0.001130479,"domain_scores_codex":[0.999885,0.00002073973,0.00001191862,0.00002162902,0.00004372883,0.00001700671],"domain_scores_gemma":[0.9998653,0.00005162605,0.00001770771,0.000005533469,0.00004301592,0.00001675234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001107436,0.0001277478,0.0002068609,0.01695466,0.0001098079,0.0002837759,0.00008105188,0.0005615525,0.01660662,0.009887036,0.03679475,0.9182754],"study_design_scores_gemma":[0.00001453719,0.000105352,0.0004907885,0.001492509,0.00007594261,0.0007509419,0.00003650451,0.00009545599,0.002591719,0.002350774,0.9919788,0.00001668367],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002658913,0.9972259,0.0003256325,0.0003976524,0.0002965975,0.000005946543,0.00002348067,0.00001499976,0.001443854],"genre_scores_gemma":[0.00141048,0.9969024,0.000281864,0.000213308,0.0001256702,0.000008729413,0.00004246611,0.000002838353,0.001012287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003984306,"threshold_uncertainty_score":0.01332879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263204099523836,"score_gpt":0.3631089124495317,"score_spread":0.3404768714542933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}